Retrospective evaluation of plasma cholesterol concentration in septic dogs and its association with morbidity and mortality: 51 cases (2005-2015)

Journal of Veterinary Emergency and Critical Care
Jack P HardyRhonda R DeCook

Abstract

To determine whether plasma cholesterol concentrations in dogs with sepsis is associated with morbidity or in-hospital mortality. Retrospective cohort study from 2005-2015. Two private referral centers. Fifty-one dogs diagnosed with sepsis. None. Dogs were classified as septic if they displayed ≥2 criteria of the systemic inflammatory response syndrome in conjunction with a documented underlying infectious cause. Dogs were excluded if they had been diagnosed previously with any concurrent illness reported to alter plasma cholesterol concentrations. Plasma cholesterol concentrations at the time of sepsis diagnosis were statistically analyzed for association with morbidity, as measured by the presence of organ dysfunction, the number of dysfunctional organs, duration of hospitalization, cost of hospitalization, and in-hospital mortality. Twenty-eight (55%) dogs survived to discharge, 15 (29%) were euthanized during hospitalization, and 8 (16%) died despite treatment. While median cholesterol concentrations were significantly different when comparing survivors to discharge versus nonsurvivors who died naturally despite treatment (P = 0.0245), they were not significantly different when comparing survivors to all nonsurvivors (P = 0...Continue Reading

References

May 1, 1986·Critical Care Medicine·A LindhS Rössner
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G C KanelR L Peters
Nov 1, 1980·The Journal of Trauma·E J CoombesG F Batstone
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·W H EttingerR B Verdery
Aug 1, 1996·Intensive Care Medicine·D GuiF Pacelli
Oct 6, 1997·Veterinary Surgery : VS·J G HauptmanN B Olivier
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·P FraunbergerD Seidel
Aug 17, 1999·Biochemical and Biophysical Research Communications·C BuechlerG Schmitz
Oct 3, 1999·Annals of Clinical Biochemistry·M A CrookW Griffiths
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·H GierensW März
Jul 12, 2003·Intensive Care Medicine·Christian Brun-BuissonIsabelle Durand-Zaleski
Oct 8, 2003·Journal of Veterinary Internal Medicine·Armelle M de LaforcadeJohn E Rush
Nov 20, 2003·Critical Care : the Official Journal of the Critical Care Forum·C Michael DunhamWilbur E Sever
Jan 28, 2004·Wiener klinische Wochenschrift·Bohumil BakalarZdenek Zadak
Jul 9, 2005·Critical Care Medicine·Clementien L VermontJan A Hazelzet
May 29, 2007·Journal of Clinical Anesthesia·Dilek MemişBeyhan Karamanlioğlu
Jul 10, 2007·The Journal of Small Animal Practice·Z Yilmaz, S Senturk
May 2, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Silke SchmitzReto Neiger
Oct 14, 2009·Journal of Veterinary Emergency and Critical Care·Constance GebhardtBarbara Kohn
Jan 2, 2010·Journal of the American Veterinary Medical Association·Eileen M KenneyScott P Shaw
Aug 25, 2010·Journal of Veterinary Emergency and Critical Care·Maureen A LuschiniGretchen L Schoeffler
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Meredith E Thoen, Marie E Kerl
Jun 4, 2014·Journal of Critical Care·Alexandra LekkouCharalambos A Gogos
Sep 13, 2014·Journal of Veterinary Emergency and Critical Care·Stefano CortelliniLindsay M Kellett-Gregory

❮ Previous
Next ❯

Citations

Jun 9, 2020·Veterinary Clinical Pathology·Carlos TorrenteAsta Tvarijonaviciute
Nov 12, 2019·Journal of Feline Medicine and Surgery·Claudia BowmanJean-Sébastien Palerme
Nov 17, 2020·Frontiers in Veterinary Science·Alessio PieriniVeronica Marchetti
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Eleonora GoriVeronica Marchetti
Nov 4, 2021·Journal of Veterinary Emergency and Critical Care·Kayla M PerryShelly Vaden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Roberta TroìaMassimo Giunti
© 2022 Meta ULC. All rights reserved