PMID: 2505424May 1, 1989Paper

Retrospective evaluation of the efficacy of regional endolymphatic polychemotherapy in kidney cancer depending on the histologic structure of the tumor

Urologii︠a︡ i nefrologii︠a︡
P S SerniakIu V Geev

Abstract

An attempt was made to differentiate the prognosis for patients with various histological patterns of renal cell carcinoma subjected to adjuvant regional endolymphatic polychemotherapy from those patients who were not. A total of 90 patients were allocated to 3 groups: the first group consisted of those persons for whom a 4-component endolymphatic therapy with 5-fluorouracil, cyclophosphamide, methotrexate, thiotepa was employed; the second group (25 patients) was administered the same preparations intravenously; the third-group patients (25 subjects) were those who after surgery were not given drugs at all. Tumor biopsy specimens were studied in detail histologically and 3 carcinoma patterns were distinguished: clear cell, granular cell and anaplastic carcinoma. The number of mitotic figures per 1,000 tumor cells was defined as well. The life-span of all anaplastic carcinoma patients was less than 5 yrs. Three-year survival was the most common in first group patients with clear cell or granular cell carcinomas. Five-year survival in patients with granular cell carcinoma was 50 per cent in the first and 11.1 per cent in the second group, while in those with clear cell carcinoma it was relatively equal in all groups. The total f...Continue Reading

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