Abstract
Significant concern has been generated about the susceptibility of captive lemurs to iron storage disease, which has led some researchers to propose husbandry changes regarding dietary iron. In the current study we sought to determine the history, severity, and prevalence of iron storage disease within a large captive lemur population. Iron concentration and hemosiderin accumulation in a target organ, the liver, were assessed in necropsy specimens from 15 different species (n=153) of lemurs over a 12-yr period at the Duke University Primate Center. Banked liver tissue was used to quantify liver iron concentration (LIC) via neutron activation analysis (NAA). Prussian blue staining was used to accentuate the presence of liver iron for evaluation using an established scoring system. Of the 153 reports examined, 49 (32%) of the animals were considered positive for the presence of hemosiderin in the liver, lymph node, duodenum, and kidney, with 36 of the 49 (73%) showing deposition of iron in the liver. Total iron scores (TIS) ranged from 0.3+/-0.3 in Lemur catta to 33.3+/-1.7 in Cheirogaleus medius. The mean LIC ranged from 209+/-1.4 microg/g wet weight in L. catta to 2957+/-414 microg/g in C. medius. Management practices may have ...Continue Reading
References
Jun 1, 1978·The Biochemical Journal·R CammackE J Hewitt
Jan 1, 1992·Basic Life Sciences·L G Butler
Jun 1, 1992·Gastroenterology·Y M DeugnierP Brissot
Dec 1, 1987·The Journal of Nutrition·B Borch-Iohnsen, K J Nilssen
Jul 1, 1981·The American Journal of Clinical Nutrition·J G ReinholdP Garzon
Mar 1, 1994·Journal of Veterinary Internal Medicine·J K HouseM V Pino
Oct 1, 1996·Nutrition Reviews·J L BeardD J Piñero
Jan 1, 1997·American Journal of Primatology·D J OverdorffA Telo
Oct 8, 1999·American Journal of Primatology·A E Müller
Feb 24, 2001·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J Schmid, J R Speakman
Feb 24, 2001·Molecular Aspects of Medicine·P T LieuY Yang
Apr 5, 2001·The Tohoku Journal of Experimental Medicine·Y Tobimatsu, R Nakamura
Jul 18, 2002·Journal of Inorganic Biochemistry·Robert R CrichtonRoberta J Ward
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·R WinikoffG-E Rivard
Nov 16, 2005·International Journal of Phytoremediation·A O FayigaR C Littell
Mar 1, 1981·Biological Trace Element Research·E D Weinberg
Nov 1, 1999·Oecologia·Joanna Fietz, Jörg U Ganzhorn
Citations
Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Randall E JungeEdward E Louis
Nov 20, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Marcus Clauss, Donald E Paglia
Feb 19, 2008·Journal of the American Veterinary Medical Association·Cathy V WilliamsIlse H Stalis
Feb 1, 2014·Journal of the American Veterinary Medical Association·Kadie M Anderson, Karen N Wolf
Jul 9, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Casey BrewerJohn C Wood
Oct 20, 2012·Journal of Comparative Pathology·R Klopfleisch, P Olias
Dec 17, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Tamara N KruseChristopher J Bonar
May 26, 2009·American Journal of Primatology·Fidiniaina RaharisonJean Sautet
Nov 23, 2010·Journal of Medical Primatology·Stéfanie V SantosJosé L Catão-Dias
Sep 28, 2010·American Journal of Primatology·Mitchell T IrwinKaren E Samonds
Aug 1, 2009·Zoo Biology·Debra A SchmidtMonty S Kerley
Mar 25, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Angelique M LeoneLisa L Farina
Sep 1, 2019·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Benoît QuintardKatia Ortiz
Nov 17, 2020·Frontiers in Veterinary Science·Maja RuettenMax Gassmann
Apr 4, 2009·The Veterinary Clinics of North America. Exotic Animal Practice·Randall E JungeJennifer Campbell