Retrospective Identification of a Broad IgG Repertoire Differentiating Patients With S. aureus Skin and Soft Tissue Infections From Controls

Frontiers in Immunology
Fabio RigatMichael Z David

Abstract

Background: Although the relevance of humoral immunity for protection against S. aureus skin and soft tissue infections (SSTIs) has been suggested by several animal and human studies, the question of which human antibodies may be protective has so far impeded the development of a safe and effective vaccine. Because most adults have developed certain anti-S. aureus antibodies due to S. aureus colonization or infection, we hypothesized that the titers of antibodies to S. aureus in uninfected controls would differ from those in infected patients and would also differ in infected patients from the time of acute infection to a 40-day convalescent serum. Methods: To test these hypotheses, we measured human antibody levels against a panel of 134 unique antigens comprising the S. aureus surfome and secretome in subjects with active culture-confirmed S. aureus SSTIs (cases) and in controls with no infection, using a novel S. aureus protein microarray. Results: Most S. aureus SSTI patients (n = 60) and controls (n = 142) had antibodies to many of the tested S. aureus antigens. Univariate analysis showed statistically weak differences in the IgG levels to some antigens in the SSTI patient (case) sera compared with controls. Antibody level...Continue Reading

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Citations

Nov 14, 2019·Current Osteoporosis Reports·Gowrishankar MuthukrishnanEdward M Schwarz
Jun 20, 2021·The Journal of Infectious Diseases·Zhaotao LiChristopher P Montgomery
Nov 26, 2021·Frontiers in Immunology·Rosanna LeuzziClarence B Creech

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Methods Mentioned

BETA
genotyping
protein array
Protein

Software Mentioned

R

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