Retrospective multicenter matched case-control study on the risk factors for narcolepsy with special focus on vaccinations (including pandemic influenza vaccination) and infections in Germany

Sleep Medicine
Doris OberleGerman Narcolepsy Study Group

Abstract

Studies associate pandemic influenza vaccination with narcolepsy. In Germany, a retrospective, multicenter, matched case-control study was performed to identify risk factors for narcolepsy, particularly regarding vaccinations (seasonal and pandemic influenza vaccination) and infections (seasonal and pandemic influenza) and to quantify the detected risks. Patients with excessive daytime sleepiness who had been referred to a sleep center between April 2009 and December 2012 for multiple sleep latency test (MSLT) were eligible. Case report forms were validated according to the criteria for narcolepsy defined by the Brighton Collaboration (BC). Confirmed cases of narcolepsy (BC level of diagnostic certainty 1-4a) were matched with population-based controls by year of birth, gender, and place of residence. A second control group was established including patients in whom narcolepsy was definitely excluded (test-negative controls). A total of 103 validated cases of narcolepsy were matched with 264 population-based controls. The second control group included 29 test-negative controls. A significantly increased odd ratio (OR) to develop narcolepsy (crude OR [cOR] = 3.9, 95% confidence interval [CI] = 1.8-8.5; adjusted OR [aOR] = 4.5, 9...Continue Reading

Citations

Jul 16, 2019·The Pediatric Infectious Disease Journal·Kathryn EdwardsSteven Black
Aug 16, 2017·Pharmacoepidemiology and Drug Safety·Doris OberleBrigitte Keller-Stanislawski
Jun 2, 2018·Current Neurology and Neuroscience Reports·Tomi SarkanenMarkku Partinen
Sep 22, 2017·The Journal of Infectious Diseases·Dimitri Poddighe
Aug 4, 2020·Journal of Translational Autoimmunity·Krister MelénIlkka Julkunen

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