Retrospective Multicenter Study Investigating the Role of Targeted Next-Generation Sequencing of Selected Cancer Genes in Mucinous Adenocarcinoma of the Lung

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Luisella RighiMauro Papotti

Abstract

Mucin-rich lung adenocarcinomas (ADCs), namely mucinous and colloid ADCs, are classified as ADC variants according to the World Health Organization 2015 classification. A correlation between morphological patterns and mutational status of these rare entities is not well established. We investigated the mutational profile of mucin-rich lung ADCs in correlation with histopathological and morphological features with the goal of identifying biological tumor characteristics of potential prognostic and therapeutic interest. A series of 54 surgically resected primary mucinous lung ADC samples were retrospectively analyzed for clinicopathological characteristics and by targeted next-generation sequencing. Fifty cases were invasive mucinous ADCs (32 pure and 18 mixed) and four were colloid-predominant ADCs. Invasive mucinous ADC cases with a pure mucinous pattern were associated with a lower risk of vascular invasion (p = 0.01), absence of signet ring cells (p = 0.03), negative nodal status (p = 0.006), and early clinical stage (p = 0.02). The most prevalent mutations involved the Kirsten rat sarcoma viral oncogene homolog gene (KRAS) and tumor protein p53 gene (TP53). Most mutations clustered in the mitogen-activated protein/protein ki...Continue Reading

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Citations

Mar 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simona VatranoAnd Mauro Papotti
Aug 10, 2018·JCI Insight·Alison K BauerSeyed Javad Moghaddam
Jan 10, 2021·Virchows Archiv : an International Journal of Pathology·Luisella RighiMauro Papotti
Oct 22, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Philipp JurmeisterMaximilian von Laffert
Jan 23, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Pengtao RenMinghua Jin

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