Retrospective review of patients treated for cyclic vomiting syndrome with topiramate.

Alimentary Pharmacology & Therapeutics
Harrison MooersThangam Venkatesan

Abstract

Practice guidelines recommend topiramate as second-line treatment for the prevention of moderate-severe cyclic vomiting syndrome (CVS) in adults. However, data are limited to small studies in children. To characterise the response to topiramate as prophylactic therapy in adults with CVS. We conducted a retrospective review of patients with CVS. Clinical characteristics, number of CVS episodes, emergency department (ED) visits, and hospitalisations the year before and after initiating topiramate were recorded. Response was defined as a global improvement in symptoms or >50% reduction in the number of CVS episodes, ED visits or hospitalisations. Sixty-five percent (88/136) of patients responded to topiramate in an intent-to-treat analysis. There was a significant decrease in the annual number of CVS episodes (18.1 vs 6.2, P < 0.0001), CVS-related ED visits (4.3 vs 1.6, P = 0.0029), and CVS-related hospitalisations (2.0 vs 1.0, P = 0.035). Logistic regression revealed that higher doses of topiramate, longer use of topiramate (≥12 months) and topiramate as monotherapy were associated with a response to treatment. Anxiety was associated with non-response to topiramate. Fifty-five percent of patients experienced side effects, and 32%...Continue Reading

References

Oct 16, 1999·The American Journal of Gastroenterology·C Prakash, R E Clouse
Aug 19, 2003·Journal of Behavioral Medicine·Mark A SykesSusan Krasner
Nov 1, 2006·Pediatric Neurology·Akgün OlmezGüzide Turanli
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ray E ClouseChandra Prakash
Dec 23, 2009·Journal of Clinical Gastroenterology·Reza A HejaziRichard W McCallum
Feb 11, 2012·Journal of Neurogastroenterology and Motility·Justin Cy Wu
May 6, 2016·Gastroenterology·Vincenzo StanghelliniNicholas J Talley
Jun 16, 2016·Journal of Neurogastroenterology and Motility·Oya B Sezer, Taner Sezer
Jan 15, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael P JonesNicholas J Talley
Jul 27, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R C SagarA C Ford
Jun 2, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Imran AzizHans Törnblom
Aug 31, 2018·Current Gastroenterology Reports·Katja KovacicThangam Venkatesan
Jun 27, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Thangam VenkatesanB U K Li

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Citations

Aug 1, 2021·Alimentary Pharmacology & Therapeutics·Vikram Rangan, Anthony J Lembo
Aug 1, 2021·Alimentary Pharmacology & Therapeutics·Harrison MooersThangam Venkatesan

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