Retrospective study comparing MR-guided radiation therapy (MRgRT) setup strategies for prostate treatment: repositioning vs. replanning

Radiation Oncology
Jung-In KimJin Ho Kim

Abstract

This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system. A total of 19 patients with prostate cancer were selected retrospectively. Weekly magnetic resonance image (MRI) scans were acquired for 5 weeks for each patient to observe the anatomic changes during the treatment course. Initial intensity-modulated radiation therapy (IMRT) plans (iIMRT) were generated for each patient with 13 coplanar 60Co beams on a ViewRay™ system. Two techniques were applied: patient repositioning and replanning. For patient repositioning, one plan was created: soft-tissue (prostate) matching (Soft). The dose distribution was calculated for each MRI with the beam delivery parameters from the initial IMRT plan. The replanning technique was used to generate the Adaptive plan, which was the reoptimized plan for the weekly MRI. The dose-volumetric parameters of the planning target volume (PTV), bladder, and rectum were calculated for all plans. During the treatment course, the PTV, bladder, and rectum were evaluated for changes in volume and the effect on dosimetric parameters. The differences between the dose-volumetric...Continue Reading

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Citations

Jul 12, 2020·Radiation Oncology·Annika MannerbergSofie Ceberg
Aug 9, 2020·Physics in Medicine and Biology·Cornel ZachiuMario G Ries
Nov 11, 2020·JCO Oncology Practice·Sanford L MeeksPatrick Kelly
Mar 30, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stefanie CorradiniClaus Belka

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Methods Mentioned

BETA
X-ray

Software Mentioned

ViewRay
Perce
iIMRT

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