Abstract
Although necrotizing pneumonia (NN) is one of the most feared complications of community-acquired pneumonia, data in pediatric patients are scarce. The objective of this article is to describe children admitted to pediatric intensive care unit (PICU) because of NN. Retrospective-prospective observational study in children admitted with NN to PICU (from January 1, 2010, to December 31, 2018). The data collected included information on disease epidemiology, PICU management, respiratory assistance and disease evolution. Fifty-one children were included, 42 of 51 had received 7-valent or 13-valent pneumococcal vaccine. Median age was 3.2 years (1.9-4.2), 15 of 51 had signs of sepsis at admission. Forty-nine patients presented pleural effusion with drainage in 46. The most common respiratory support modality was high-flow oxygen nasal cannula (17/51). Computed tomography was the gold standard for diagnosis. Etiologic diagnosis was obtained in 34 of 51, and pneumococcus was isolated in 29 of 34. In all of these cases, initial detection was made by capsular antigen in pleural fluid. Children with pneumococcal NN had fewer days of evolution prior to PICU admission (P = 0.041). Cefotaxime with clindamycin was used in 49 of 51. Surgery w...Continue Reading
References
Feb 1, 1994·Chest·C PennerR Long
Jan 25, 2008·The European Respiratory Journal·G S SawickiA A Colin
Apr 11, 2008·Clinical Microbiology Reviews·L Beth Gadkowski, Jason E Stout
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey M BenderCarrie L Byington
Oct 7, 2009·European Journal of Pediatrics·Juan Casado FloresJulio Casal
Oct 9, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chen-Yin LaiLuan-Yin Chang
Feb 12, 2013·Advances in Therapy·Tin Tin Htar MyintEric Bonnet
Jun 1, 2013·The Pediatric Infectious Disease Journal·Chloé LemaîtreMathie Lorrot
Feb 25, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A FletcherG Sylvester
Dec 3, 2014·The Pediatric Infectious Disease Journal·Yu-Chia HsiehUNKNOWN Taiwan Pediatric Infectious Diseases Alliance
Dec 4, 2014·Advances in Experimental Medicine and Biology·Katarzyna KrenkeMarek Kulus
Oct 16, 2015·BMC Infectious Diseases·Myint Tin Tin HtarHeinz-Josef Schmitt
Jul 9, 2016·Pediatric Pulmonology·Ira ErlichmanEitan Kerem
Jan 19, 2017·Critical Care Medicine·Andrew RhodesR Phillip Dellinger
Aug 5, 2017·Pneumonia·I Brent MastersKeith Grimwood
Mar 8, 2018·Children·Tahereh HajiTom Kovesi
Oct 26, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heather L SingsLuis Jodar
Mar 25, 2019·Vaccine·Juan J PicazoUNKNOWN Heracles Study Group
Apr 15, 2019·Vaccine·Chiara AzzariSilvia Ricci
Sep 29, 2019·The Journal of Pediatrics·Corinne LevyRobert Cohen