Retrospective study of 23 pathologically proven cases of central nervous system tuberculomas

Clinical Neurology and Neurosurgery
Cicek BayindirBilge Bilgic

Abstract

Extrapulmonary manifestations of tuberculosis involving the central nervous system (CNS) due to haematogenous spread are not a rare entity. It presents as meningitis or tuberculoma. Tuberculoma is a granulomatous inflammatory process mimicking a neoplasm radiologically, so usually a biopsy is performed. Our study consisted of 23 pathologically proven cases of tuberculomas between 1988 and 2003. Patients were discussed clinically, radiologically and histologically. Headache, fever, weight loss and weakness are the most common clinical manifestations. Our patient's ages vary from 3 to 67 years with a mean of 31.8 years. Ninety-five percent of patients had bad social, economic and nutritional conditions. None of them were infected by human immunodeficiency virus (HIV). All patients had similar contrast-enhancing lesions radiologically. The majority of tuberculomas were located supratentorially. Only one patient presented two foci of (cerebral and cerebellar) tuberculomas. Nineteen tuberculomas were intracerebral; two were located in the cerebellum and one was intramedullary. Among those lesions, one cavernous sinus tuberculoma and one sellar tuberculoma were identified. Only two patients underwent stereotactic biopsy and 21 patien...Continue Reading

References

Sep 23, 1992·JAMA : the Journal of the American Medical Association·K M De CockS B Lucas
Mar 31, 1998·Postgraduate Medical Journal·V LalS Prabhakar
Jun 16, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Hernández-AlbújarJ J Vázquez
Jun 16, 2000·European Journal of Internal Medicine·O FainM Thomas
Sep 19, 2000·Journal of Magnetic Resonance Imaging : JMRI·M H Pui
Aug 3, 2001·Surgical Neurology·R RebaiH Ben Mansour
Dec 5, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Satish SathyanarayanaAnil Nanda
Feb 25, 2003·The Tohoku Journal of Experimental Medicine·Nejmi Kiymaz, Bayram Cirak
Aug 15, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hakan TunaAhmet Erdogan
Feb 1, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Lieh-Bang Liou, Wan-Ju Chao

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Citations

Nov 24, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C LiuC A Glaser
Feb 5, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Farid RadmaneshMostafa El Khashab
Oct 1, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christina A Nelson, Joseph R Zunt
Jun 28, 2012·The Neurologist·Ping-Song ChouA-Ching Chao
Sep 16, 2008·Neurosurgery·Walter A Hall, Charles L Truwit
Sep 17, 2011·Internal Medicine·Zhengqi LuXueqiang Hu
Oct 4, 2011·Journal of Neurosurgery. Pediatrics·Matthew A AdamoIan F Pollack
Jun 1, 2010·Nuclear Medicine and Molecular Imaging·Dae-Weung KimSang-Ah Jung
May 1, 2012·Revue des maladies respiratoires·J Mazza-StalderJ-P Janssens
Sep 24, 2010·Seminars in Diagnostic Pathology·Vani SantoshShankar S Krishna
Apr 29, 2008·The Journal of Emergency Medicine·James D KrygowskiFrancis L Counselman
Mar 4, 2008·Clinical Imaging·Guner SonmezEsref Kizilkaya
Dec 28, 2007·Clinical Neurology and Neurosurgery·Soma Sahaiu-Srivastava, Brenda Jones
May 22, 2008·Journal of the National Comprehensive Cancer Network : JNCCN·Steven S BremAllen K Sills
Mar 14, 2013·Journal of Paediatrics and Child Health·Pascallina L C Ting, Robert Norton
Sep 12, 2006·Clinical Neurology and Neurosurgery·Thomas S Skoglund, Daniel Nilsson
Jun 24, 2011·Scandinavian Journal of Infectious Diseases·J Daniel KellyDavid J Tweardy
Aug 13, 2014·Case Reports in Medicine·Dulce Bonifacio-DelgadilloArturo Garcia-Marquez
May 17, 2014·Journal of Child Neurology·Amol RahejaBhawani Shankar Sharma
Apr 11, 2008·Journal of Child Neurology·Catherine Zorn-OlexaMichel Fischbach
Dec 25, 2009·Journal of Child Neurology·Faten TinsaSouad Bousnina
Dec 6, 2007·Journal of Korean Medical Science·Jae Sook AhnHyeoung Joon Kim
May 5, 2020·Wellcome Open Research·Suzaan MaraisUNKNOWN Tuberculous Meningitis International Research Consortium
Feb 13, 2017·Acta neurochirurgica·Nishanth SadashivaBhagavatula Indira Devi
Mar 7, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Xiao XiaoYan Ju
Jun 11, 2021·Neuro-ophthalmology·Alvaro OrtizMarcela Peralta
Jul 1, 2021·British Journal of Neurosurgery·Valentina TardivoFotios Kalfas

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