Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service

Journal of Clinical Pharmacy and Therapeutics
H CapelleM Montana

Abstract

With the increasing use of cancer chemotherapy agents, hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum salts and pemetrexed in the treatment of patients with non-small cell lung cancers or malignant pleural mesothelioma. A single-centre retrospective study was performed for 2 years. Patients treated with the drugs of interest for an advanced or metastatic non-small cell lung cancers or malignant pleural mesothelioma and who experienced hypersensitivity reactions symptoms were eligible for this study. Clinical symptoms of hypersensitivity reactions, population characteristics and administered chemotherapy regimens were identified. The hypersensitivity reactions frequency was rare (1.2%) and concerned 17 patients in our study. Typical clinical features of immediate hypersensitivity reactions associated with treatment were observed for nine patients (anaphylactic reactions for three cases, angioedema and hypotension associated with asthenia and heat in one case, respectively, and other cutaneous symptoms in the remaining four c...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MarkmanJ Belinson
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O S BreathnachB E Johnson
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M ZanottiM Markman
Feb 16, 2002·Contact Dermatitis·A BarbaudUNKNOWN European Society of Contact Dermatitis
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurie MarkmanJerome Belinson
Jan 27, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S Sliesoraitis, P J Chikhale
Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gilberto LopesLuis E Raez
Jan 30, 2007·The Journal of Allergy and Clinical Immunology·Vanessa Leguy-SeguinEvelyne Collet
Feb 23, 2007·Revue des maladies respiratoires·F TouraineF Bonnaud
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Jul 8, 2008·Revue de pneumologie clinique·S CouraudF Mornex
Aug 14, 2008·Clinical and Experimental Dermatology·A BrackeJ Lambert
Aug 30, 2008·Therapeutics and Clinical Risk Management·Ranjit K Goudar
Oct 14, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ruth GomezAndreas du Bois
Mar 27, 2010·The Journal of Allergy and Clinical Immunology·Pauline Guyot-CaquelinAnnick Barbaud
May 7, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M D ChirlaqueC Navarro
Jul 17, 2010·Inflammation & Allergy Drug Targets·Ekaterini SyrigouKostas Syrigos
Oct 5, 2010·Metal-based Drugs·Nektaria MakriliaMuhammad Wasif Saif
Jun 18, 2011·Journal of the American Academy of Dermatology·Magalys VitielloFrancisco A Kerdel
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Belen EguiaJacques Cadranel
Apr 10, 2012·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·S Cortijo-CascajaresA Herreros de Tejada
Mar 12, 2013·Acta Oncologica·Binay Kumar Shah, Yvonne Hewett
Jun 18, 2014·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Héloise CapelleMarc Montana
Aug 5, 2014·Current Oncology·J BoulangerUNKNOWN Comité de l’évolution des pratiques en oncologie

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Citations

Nov 20, 2018·Journal of Clinical Pharmacy and Therapeutics·Amir Rezazadeh, Maryam Taghizadeh-Ghehi
May 4, 2021·International Journal of Clinical Pharmacy·Laura Pedraza-NietoMaría José Otero

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