Abstract
To determine the direct healthcare costs associated with the onset of chronic nonvalvular atrial fibrillation (CNVAF), warfarin utilization and the occurrence of cerebrovascular events in a commercially-insured population. This retrospective, observational cohort study utilized medical and pharmacy claims from a large, geographically diverse managed-care organization (N = 18.5 million) to identify continuously benefit-eligible CNVAF patients > or =45 years of age without prior valvular disease or warfarin use between January 1, 2001 and June 1, 2002. All patients were followed at least 6 months, until plan termination or the end of study follow-up. Stroke risk was assessed using the CHADS(2) (stroke-risk) index; warfarin use was defined as having filled at least one pharmacy claim. Inpatient and outpatient cost benchmarks were utilized to estimate total direct healthcare costs (pre- and post-AF index claim). For patients with transient ischemic attacks (TIA), ischemic stroke (IS) and major bleed (MB) total direct healthcare costs were also assessed. The limitations of this study included a descriptive retrospective study design without a comparison group or adjustment for baseline disease severity and drug exposure, as well as,...Continue Reading
References
Oct 1, 1991·Annals of Neurology·G W AlbersP Petersen
Mar 1, 1990·Mayo Clinic Proceedings·S J PhillipsR L Frye
Aug 1, 1989·Australian and New Zealand Journal of Medicine·F R LakeD L Rosman
Mar 13, 1995·Archives of Internal Medicine·W M FeinbergR G Hart
Jul 11, 1994·Archives of Internal Medicine
Aug 1, 1994·The American Journal of Cardiology·C D FurbergP M Rautaharju
Apr 3, 1999·Stroke; a Journal of Cerebral Circulation·M N DiringerA W Dromerick
Apr 13, 2000·Archives of Internal Medicine·G P SamsaJ Bian
May 10, 2001·JAMA : the Journal of the American Medical Association·A S GoD E Singer
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Oct 12, 2002·Clinical Cardiology·Thomas A Buckingham, Robert Hatala
Mar 15, 2003·The American Journal of Medicine·Susana PenadoJosé A Riancho
Aug 25, 2004·The American Journal of Cardiology·Farhat KhairallahSamir Saba
Oct 13, 2004·Circulation·Brian F GagePalle Petersen
Dec 9, 2004·Pharmacotherapy·Ann K WittkowskyOle Hauch
Dec 15, 2004·Chest·Matthew W ReynoldsLuba Nalysnyk
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Paul S J MillerLalit Kalra
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 17, 2009·Birth·Michelle J K Osterman
Jan 1, 1995·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·UNKNOWN Stroke Prevention in Atrial Fibrillation Investigators
Citations
Apr 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas ReinholdBernd Brüggenjürgen
Oct 20, 2012·Cardiology Research and Practice·Catherine J MercaldiNing Wu
Feb 14, 2014·PloS One·Luciane Cruz LopesGordon Guyatt
Apr 14, 2012·ClinicoEconomics and Outcomes Research : CEOR·Steven N Singh
Nov 22, 2011·Journal of Pharmacy Practice·Arpit Kashyap, Chenghui Li
Sep 20, 2015·American Heart Journal·Peter A NoseworthyDouglas L Packer
Jul 30, 2011·Thrombosis and Haemostasis·Claire KeoghTom Fahey
Jul 23, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Christian Becker
Apr 12, 2013·Expert Opinion on Pharmacotherapy·Allison BurnettCharles E Mahan
Oct 1, 2013·Clinical Therapeutics·Steven B DeitelzweigJohn Graham
Jul 30, 2014·BMC Health Services Research·Kathleen LangJoseph Menzin
Jul 1, 2016·PloS One·Xue LiEsther W Chan
Apr 25, 2015·Journal of the American Heart Association·Maria C BennellHarindra C Wijeysundera
Nov 2, 2014·Stroke; a Journal of Cerebral Circulation·Niamh HannonPeter J Kelly
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Niamh HannonPeter J Kelly
Apr 4, 2019·Journal of Medical Economics·Heather M RozjabekEric D Peterson
Jan 15, 2016·Medicine·Elisabeth B MarshRebecca F Gottesman
Apr 23, 2013·The Annals of Pharmacotherapy·Birgitta von SchéeleWinghan Jacqueline Kwong
Dec 14, 2017·Current Medical Research and Opinion·Henry J HenkLien Vo
Apr 2, 2021·Frontiers in Neurology·Patrick D LydenBerislav V Zlokovic
Jul 20, 2020·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Georgia KourlabaNikos Maniadakis