Retrospective study on efficacy of a paclitaxel combined with a leucovorin and fluorouracil regimen for advanced gastric cancer

Tumori
Baoyu YangQiang Chen

Abstract

To investigate the efficacy of paclitaxel combined with a leucovorin and 5-fluorouracil regimen (PLF regimen; q2w) as neoadjuvant chemotherapy (NCT) for advanced gastric cancer. A total of 183 patients with advanced gastric cancer who underwent 3 cycles of PLF regimen chemotherapy before surgery and received surgery 2 weeks after chemotherapy were enrolled as a treatment group. A total of 184 patients with advanced gastric cancer and no NCT during the same period were enrolled as the controls and treated with surgery. Both groups underwent a D2 radical gastrectomy and the standard postoperative adjuvant chemotherapy. In the NCT group, there were 19 cases of complete remission, 86 cases of partial remission, 72 cases of stable disease, and 6 cases of progressive disease, with an overall response rate of 57.4%. The R0 resection rate was higher than in the control group (85.2% vs 61.4%, p < .05). In the NCT group, 12 cases of esophagogastric cancer (20.7%) showed complete remission and 32 cases (55.2%) showed partial remission, while 7 cases of distal gastric cancer (5.6%) showed complete remission and 54 cases (43.2%) showed partial remission. Pathologic complete remission was higher for esophagogastric cancer than for distal gas...Continue Reading

References

Sep 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H WilkeH Knipp
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Mar 6, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Michiya KobayashiKazuhiro Hanazaki
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Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc YchouPhilippe Rougier
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Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He

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