Retrosplenial cortex lesions impair water maze strategies learning or spatial place learning depending on prior experience of the rat

Behavioural Brain Research
Donald Peter CainFrancis Boon

Abstract

There has been debate whether lesions strictly limited to retrosplenial (RS) cortex impair spatial navigation, and how robust and reliable any such impairment is. The present study used a detailed behavioral analysis with naive or strategies-pretrained rats given RS lesions and trained in a water maze (WM). Naive RS lesioned rats failed to acquire the required WM strategies throughout training. Strategies-pretrained RS lesioned rats were specifically impaired in spatial place memory without a WM strategies impairment. Additional training overcame the spatial memory impairment. Thus the behavioral consequences of the lesion depend on the specific previous experience of the animal. The use of appropriate training and testing techniques has revealed experience-dependant dissociable impairments in WM strategies learning and in spatial memory, indicating that RS cortex is involved in both forms of learning.

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Citations

Jun 22, 2011·Behavioral Neuroscience·Siobhan RobinsonDavid J Bucci
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura KentonDonald P Cain
Jul 1, 2011·BMC Neuroscience·Sung-Soo ParkStuart Maudsley
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J ClarkJeffrey S Taube
Nov 26, 2008·Neurobiology of Learning and Memory·Christopher S Keene, David J Bucci
Nov 27, 2008·The European Journal of Neuroscience·Helen H J PothuizenSeralynne D Vann
Apr 11, 2009·Hippocampus·Kara L Agster, Rebecca D Burwell
Sep 28, 2015·Behavioral and Brain Functions : BBF·Yuan YangJingjing Li
Mar 1, 2012·Neuron·Jonathan R WhitlockEdvard I Moser
May 11, 2013·Behavioural Brain Research·Magdalena Mendez-LopezMathieu Wolff
Oct 6, 2009·Neuropsychologia·John P Aggleton
Jun 1, 2014·Neurobiology of Learning and Memory·David J Bucci, Siobhan Robinson
Jun 5, 2016·Brain Structure & Function·Xiang-Zhen KongJia Liu
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Feb 14, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sydney TraskFred J Helmstetter

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