Retrosternal pain is an early indicator of oxygen toxicity

The American Review of Respiratory Disease
A B MontgomeryJ F Murray

Abstract

To determine the most sensitive early indicator of toxicity from exposure to O2, we measured respiratory clearance of 99mTc-diethylenetriamine pentaacetate (Tc-DTPA), pulmonary function, serum Factor VIII antigen, and plasma fibronectin values and monitored symptoms in six normal volunteers who breathed 21, 40, and 100% O2, administered in random order, for 17 h at least 1 wk apart. Twenty minutes after beginning O2, arterial PO2 differed among the three exposure groups. After exposure to the three concentrations of O2, there were no differences in Tc-DTPA clearance, vital capacity, FEV1/FVC, diffusing capacity, Factor VIII antigen, or fibronectin concentration. In contrast, all subjects complained of retrosternal pain during and after breathing 100% O2 (p less than 0.001). We conclude that with exposure to 100% O2, retrosternal pain, presumably from tracheal inflammation, occurs before detectable abnormalities of epithelial solute permeability (Tc-DTPA clearance), endothelial O2 injury (fibronectin concentration and Factor VIII), or pulmonary function. These findings indicate that symptoms are more sensitive than signs in detecting early O2 toxicity.

References

Oct 1, 1985·Journal of Applied Physiology·J D MarksJ F Murray
Aug 1, 1984·The American Review of Respiratory Disease·M GlassA B Fisher
Oct 13, 1983·The New England Journal of Medicine·W B DavisR G Crystal

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Citations

Jan 1, 1990·International Archives of Occupational and Environmental Health·J R JauchemP C Johnson
Oct 7, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mario SchietromaGianfranco Amicucci
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Jun 5, 2021·American Journal of Respiratory and Critical Care Medicine·Chad H HochbergRoy G Brower

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