Retrotransposon-induced mosaicism in the neural genome

Open Biology
Gabriela O BodeaGeoffrey J Faulkner

Abstract

Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain. Retrotransposition in the developing brain, as well as during adult neurogenesis, provides a milieu in which neural diversity can arise. Dysregulation of retrotransposon activity may also contribute to neurological disease. Here, we review recent reports of retrotransposon activity in the brain, and discuss the temporal nature of retrotransposition and its regulation in neural cells in response to stimuli. We also put forward hypotheses regarding the significance of retrotransposons for brain development and neurological function, and consider the potential implications of this phenomenon for neuropsychiatric and neurodegenerative conditions.

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Citations

Nov 17, 2019·Cells·Christian SchmeerOtto W Witte
Dec 12, 2019·Open Biology·Isabel Espinosa-MedinaTzumin Lee
Mar 8, 2020·Environmental and Molecular Mutagenesis·Brunella Del Re, Gianfranco Giorgi
May 6, 2020·International Journal of Molecular Sciences·Jonathan D TurnerMartin Diewald
Apr 22, 2020·Nucleic Acids Research·Cory J SmithGeorge M Church
Aug 17, 2019·Biological Psychiatry·Maryem A Hussein, David A Ross
Jan 23, 2021·Reproductive Sciences·Fabiana B KohlrauschDavid L Keefe
Jan 10, 2020·Cancer Genetics·Andrea Cervantes-AyalcMiguel Ángel Velázquez-Flores
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Samuel E RossOzren Bogdanovic
Apr 23, 2021·PLoS Genetics·Richard M KeeganJosh Dubnau
May 1, 2021·Life·Roberto FerrariGiorgio Dieci
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Franziska VierlMagdalena Götz
Jan 4, 2022·Journal of Theoretical Biology·Hessameddin Akhlaghpour

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Methods Mentioned

BETA
transgenic
PCR

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