Retroviral capsid determinants of Fv1 NB and NR tropism

Journal of Virology
Anthony StevensJonathan P Stoye

Abstract

The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.

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Citations

Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melvyn W YapJonathan P Stoye
Feb 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuhe YanChristine A Kozak
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Harriet C T GroomKate N Bishop
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Laura HilditchJonathan P Stoye
Nov 10, 2006·Journal of Virology·Jared L SpidelJohn W Wills
Mar 29, 2013·Journal of Virology·Sadayuki Ohkura, Jonathan P Stoye
Jul 30, 2005·Journal of Virology·Mark P DoddingJonathan P Stoye
Nov 25, 2005·Journal of Virology·Dyana T SaenzEric M Poeschla
Dec 2, 2010·Retrovirology·Christine A Kozak
Mar 28, 2013·PloS One·Kalani HalemanoMario L Santiago
Jan 2, 2008·PLoS Pathogens·Pierre V MaillardDidier Trono
Mar 8, 2014·PLoS Pathogens·Melvyn W YapJonathan P Stoye
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ioanna TriviaiCarol Stocking
Nov 15, 2008·Journal of Molecular Biology·Gulnahar B MortuzaIan A Taylor
Jan 15, 2005·Current Biology : CB·Melvyn W YapJonathan P Stoye
Jul 16, 2014·Virus Research·Smita Nair, Alan Rein
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Jun 28, 2016·Retrovirology·Wilson LiJonathan P Stoye
Sep 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·George R YoungJonathan P Stoye
Nov 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kun QuJohn A G Briggs

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