Retroviral restriction factors and infectious risk in xenotransplantation.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Y MeijeJay A Fishman

Abstract

The clinical application of xenotransplantation poses immunologic, ethical, and microbiologic challenges. Significant progress has been made in the investigation of each of these areas. Among concerns regarding infectious risks for human xenograft recipients is the identification in swine of infectious agents including porcine endogenous retroviruses (PERV) that are capable of replication in some human cell lines. PERV replication has, however, been difficult to demonstrate in primate-derived cell lines and in preclinical studies of non-human primates receiving porcine xenografts. Endogenous 'retroviral restriction factors' are intracellular proteins and components of the innate immune system that act at various steps in retroviral replication. Recent studies suggest that some of these factors may have applications in the management of endogenous retroviruses in xenotransplantation. The risks of PERV infection and the potential role of retroviral restriction factors in xenotransplantation are reviewed in detail.

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Citations

Apr 12, 2012·Clinical Microbiology Reviews·Joachim Denner, Ralf R Tönjes
Feb 11, 2011·Journal of Virology·Eva DörrschuckRalf R Tönjes
Dec 17, 2010·Xenotransplantation·Yasuhiro Takeuchi, Jay Fishman
Jan 18, 2013·The Journal of General Virology·Gernot WolfFinn Skou Pedersen
Aug 17, 2016·Viruses·Joachim Denner
Mar 8, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jay A Fishman
Nov 14, 2017·Xenotransplantation·Linda ScobieHenk-Jan Schuurman
Dec 2, 2017·Xenotransplantation·David K C CooperRalf R Tönjes
Mar 2, 2011·Current Opinion in Organ Transplantation·Nicolas J MuellerLinda Scobie
Oct 10, 2018·Current Opinion in Organ Transplantation·Anoma Nellore
Jul 25, 2017·Transplantation·David K C CooperDavid H Sachs
Jan 12, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Élida Cleyse Gomes da MataElisabeth Ferroni Schwartz
Sep 29, 2018·Xenotransplantation·Anoma Nellore, Jay A Fishman

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