PMID: 3212891Nov 1, 1988Paper

Retrovirus-associated ovine pulmonary carcinoma (sheep pulmonary adenomatosis) and lymphoid interstitial pneumonia. I. Lesion development and age susceptibility

Veterinary Pathology
R H RosadioJ C DeMartini

Abstract

To determine the lesion development of retrovirus-induced ovine pulmonary carcinoma (OPC), ten neonatal lambs were inoculated intratracheally with either 1) lung fluid preparations derived from a sheep with Type D retrovirus-associated OPC and concurrent ovine lentivirus (OvLV)-associated lymphoid interstitial pneumonia (LIP) (n = 8); or 2) lung fluid from a sheep with only OvLV-LIP (n = 2). Seven of eight neonates that received Type D retrovirus-associated OPC/OvLV-LIP lung fluid developed both OPC and LIP lesions between 9 and 32 weeks after inoculation. Mild OPC lesions consisted of foci of type II alveolar epithelial cells lining alveoli surrounded by minimal alveolar macrophage infiltrates. More severe OPC lesions consisted of multifocal aggregates of cuboidal to columnar neoplastic cells forming acini or masses associated with abundant alveolar macrophage infiltrates. Lesions of LIP consisted of peribronchiolar and perivascular lymphoid hyperplasia and heterogeneous interstitial leukocytic infiltrates. The two neonates that received OvLV-LIP lung fluid developed rapid and severe LIP, but not OPC lesions. Two lambs (inoculated as neonates with virus-free lung fluid) and three lambs (uninoculated contacts) served as control...Continue Reading

Citations

Dec 1, 1989·Veterinary Immunology and Immunopathology·F J MeyersJ C DeMartini
Dec 10, 1991·Biochimica Et Biophysica Acta·D L Buchhagen
Jul 1, 1996·The British Veterinary Journal·S J HechtJ C Demartini
Feb 3, 1998·Trends in Microbiology·M PalmariniJ M Sharp
Aug 19, 2005·American Journal of Respiratory Cell and Molecular Biology·York E Miller
Dec 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Fabienne ArcherCaroline Leroux
Mar 1, 1993·Research in Veterinary Science·L GonzálezC Saez de Ocariz
Feb 19, 2010·Journal of Comparative Pathology·D J GriffithsC Cousens
Nov 1, 1992·Veterinary Pathology·K J Cremer, J Gruber
May 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·M Bouljihad, H W Leipold
May 21, 2019·Frontiers in Oncology·Mark E GrayDavid Argyle

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