Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha

Proceedings of the National Academy of Sciences of the United States of America
Theodora HatziioannouPaul D Bieniasz

Abstract

Mammalian cells express several factors that act in a cell-autonomous manner to inhibit retrovirus replication. Among these are the Friend virus susceptibility factor 1/lentivirus susceptibility factor 1/restriction factor 1 (Ref1) class of restriction factors, which block infection by targeting the capsids of diverse retroviruses. Here we show that lentivirus susceptibility factor 1 and Ref1 are species-specific variants of tripartite interaction motif 5alpha (TRIM5alpha), a cytoplasmic body component recently shown to block HIV-1 infection in rhesus macaque cells, and can indeed block infection by widely divergent retroviruses. Depletion of TRIM5alpha from human cells relieved restriction of N-tropic murine leukemia virus (N-MLV), and expression of human TRIM5alpha in otherwise nonrestricting cells conferred specific resistance to N-MLV infection, indicating that TRIM5alpha is Ref1 or an essential component of Ref1. TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys displayed different but overlapping restriction specificities that were quite accurately predicted by the restriction properties of the cells from which they were derived. All TRIM5alpha variants could inhibit infection by at least two diff...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P Jolicoeur, D Baltimore
Dec 1, 1983·Journal of Virology·L DesGroseillers, P Jolicoeur
Nov 1, 1995·The Journal of General Virology·R ShibataA Adachi
Jun 25, 1998·Revue Scientifique Et Technique·J P Stoye
Jan 5, 1999·Science·B K GanserW I Sundquist
Nov 13, 1999·Journal of Virology·W HofmannJ Sodroski
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·G TowersO Danos
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simone CowanPaul D Bieniasz
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Caroline BesnierGreg Towers
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carsten MünkNathaniel R Landau
Jan 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neeltje A KootstraInder M Verma
Jan 30, 2003·The EMBO Journal·Theodora HatziioannouGreg J Towers
Mar 29, 2003·Journal of Virology·Juan Martin-SerranoPaul D Bieniasz
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jun 26, 2003·Trends in Microbiology·Paul D Bieniasz
Aug 5, 2003·Nature Medicine·Greg J TowersPaul D Bieniasz
Dec 3, 2003·Journal of Virology·Caroline BesnierGreg J Towers
Dec 25, 2003·Journal of Virology·Theodora HatziioannouPaul D Bieniasz

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Citations

Mar 9, 2006·Current HIV/AIDS Reports·Omar Perez, Thomas J Hope
Jan 23, 2010·Journal of the American Chemical Society·Yun HanTatyana Polenova
Mar 1, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mayumi OaklandPaul B McCray
Nov 29, 2012·Molecular Therapy. Nucleic Acids·Patrick L SinnPaul B McCray
Oct 22, 2004·Nature Immunology·Paul D Bieniasz
Aug 3, 2004·Nature Medicine·Warner C Greene
Sep 22, 2005·Nature Reviews. Microbiology·Sébastien NisoleAli Saïb
Mar 13, 2012·Nature Structural & Molecular Biology·Matthew E C CainesLeo C James
Nov 18, 2005·Gene Therapy·J L Anderson, T J Hope
Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maarten A N RitsNeeltje A Kootstra
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sam J WilsonGreg J Towers
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cesar A VirgenTheodora Hatziioannou
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Harriet C T GroomKate N Bishop
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven J SollPaul D Bieniasz
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ray Malfavon-BorjaHarmit Singh Malik
Sep 3, 2010·The Journal of Biological Chemistry·Seiga OhmineYasuhiro Ikeda
Dec 21, 2010·The Journal of Biological Chemistry·Pierre V MaillardDidier Trono
Dec 17, 2008·The Journal of Biological Chemistry·Mario PerkovicCarsten Münk
Apr 12, 2012·Molecular & Cellular Proteomics : MCP·Jonathan WoodsmithChris M Sanderson
Aug 19, 2011·AIDS Research and Human Retroviruses·Abdul A Waheed, Eric O Freed
Oct 13, 2005·Human Gene Therapy·Greg J Towers
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stuart Neil, Paul Bieniasz
Mar 30, 2007·Molecular Biology of the Cell·Edward M CampbellThomas J Hope
Nov 26, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Feng-Liang LiuYong-Tang Zheng
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melvyn W Yap, Jonathan P Stoye
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Michael H Malim, Paul D Bieniasz
Jun 26, 2007·Science·Shari M KaiserMichael Emerman
Apr 23, 2010·Journal of Virology·Lesa R Black, Christopher Aiken
May 16, 2008·Journal of Virology·Sam J WilsonGreg J Towers

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