PMID: 8453268Feb 1, 1993Paper

Retroviruses: delivery vehicle to the liver

Current Opinion in Genetics & Development
M Grossman, J M Wilson

Abstract

Liver-directed gene therapy holds great promise for the treatment of inherited metabolic disease. Two strategies have emerged. Ex vivo gene therapy involves the transplantation of autologous hepatocytes transduced with recombinant retroviruses while in culture. The feasibility of this approach has been demonstrated in several animal models, and a human trial has been initiated. An alternative strategy uses recombinant viruses to deliver the transgene directly to hepatocytes in vivo.

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Citations

Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J K YeeT Friedmann
Feb 18, 1999·Human Gene Therapy·J L De GodoyO Soubrane
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Mar 1, 1995·Annals of Surgical Oncology·S P GagandeepA R Kinsella

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