Return of ovulation following a single injection of depo-medroxyprogesterone acetate: a pharmacokinetic and pharmacodynamic study

P T LanE Diczfalusy


The effect of a single dose of 150 mg of depo-medroxyprogesterone acetate (DMPA) on pituitary, ovarian and endometrial function was assessed in relation to the peripheral levels of the compound in 8 women. The levels of medroxyprogesterone acetate (MPA), follitropin (FSH), lutropin (LH), prolactin, estradiol (E2) and progesterone ( Prog .) were measured 3 times a week during a pretreatment (control) cycle and then daily during postinjection weeks 14-17, 22-25 and 30-33. An endometrial biopsy specimen was obtained during postinjection weeks 17, 25 and 33. In three out of 8 subjects the daily hormone assays carried out during postinjection weeks 30-33 indicated anovulatory periods; in these subjects peripheral blood was drawn daily during postinjection weeks 46-49 and a fourth endometrial biopsy was taken during week 49.


Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A OrtizD R Mishell
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Jul 1, 1967·British Journal of Preventive & Social Medicine·T Khosla, C R Lowe
May 1, 1980·Acta Endocrinologica·B M LandgrenE Diczfalusy


May 15, 2008·Contraception·Markus J SteinerCharles Morrison
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May 3, 2007·Obstetrics and Gynecology Clinics of North America·Stephanie B Teal, David M Ginosar
Oct 2, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Maurand CappellettiKim Wallen
Jun 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B M Landgren
Dec 27, 2018·AIDS·Renee HeffronPartners PrEP Study and Partners in Prevention HSV/HIV Transmission Study Teams
Apr 1, 1986·Journal of Obstetrics and Gynaecology·K Fotherby, G Howard
Apr 19, 2019·AIDS Research and Human Retroviruses·Andrea ThurmanGustavo F Doncel

Related Concepts

Contraceptive Agents, Female
Follicle Stimulating Hormone
Adgyn Medro
Progesterone, (17 alpha)-Isomer
Medroxyprogesterone 17-Acetate, (6 beta)-Isomer

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