Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death

Cell Chemical Biology
Marcin Poreba, Guy S Salvesen

Abstract

In a recent issue of Cell Chemical Biology, Taabazuing et al. (2017) reveal a bidirectional interplay between pathways leading to apoptosis and pyroptosis, two forms of regulated cell death with opposing inflammatory outcomes. The outcome is sealed by differential cleavage of the key pyroptosis execution substrate gasdermin D such that inflammatory caspases activate it but apoptotic caspases prevent its activation.

Citations

Jun 20, 2020·The Journal of Biological Chemistry·Betsaida Bibo-VerdugoGuy S Salvesen

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