Reuptake of L-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters

Neuroscience Letters
K KannariMasayuki Baba

Abstract

The aim of our present study was to determine whether exogenous L-DOPA-derived extracellular dopamine (DA) in the denervated striatum is taken up via serotonin (5-HT) transporters. Rats with dopaminergic denervation by 6-hydroxydopamine were injected with L-DOPA 50 mg/kg (i.p.) and extracellular DA levels in the denervated striatum were measured using in vivo microdialysis technique. During the experiments, fluoxetine, a selective serotonin reuptake inhibitor, was locally perfused into the striatum through the microdialysis probe. Cumulative amounts of L-DOPA-derived extracellular DA during 300 min were increased by fluoxetine dose-dependently (10 microM and 50 microM). These results suggest that reuptake of DA via 5-HT transporters plays an important role in the clearance of L-DOPA-derived DA from the extracellular space when dopaminergic neurons are extensively denervated.

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Citations

Jul 2, 2010·Science Translational Medicine·Marios PolitisPaola Piccini
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mads Breum LarsenSusan G Amara
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason Peter TwohigEddie C Y Wang
Feb 18, 2014·The Journal of Clinical Investigation·Marios PolitisPaola Piccini
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May 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Marios PolitisPaola Piccini
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Jun 12, 2012·Parkinson's Disease·Iciar Aviles-OlmosThomas Foltynie
Dec 24, 2013·Neuroscience·N NevalainenI Strömberg
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Mar 20, 2018·Molecular Brain·Ernest Dallé, Musa V Mabandla
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Nov 30, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Samantha M MeadowsChristopher Bishop

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