Reusable molecular sensor based on photonic activation control of DNA probes.

Biomedical Optics Express
Takahiro NishimuraJun Tanida

Abstract

We propose a photoactivatable and resettable molecular sensor using DNA probes. The functionality is achieved by reversible change of DNA structure induced via photonic signals. Based on the mechanism, the sensor can detect target molecules at a desired instant and can be returned to its initial state after detection. The experimental results demonstrate that the concentrations of the target molecules are detected correctly and repeatedly according to the light signal.

References

Oct 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Diana P BratuSanjay Tyagi
Feb 7, 2008·Chembiochem : a European Journal of Chemical Biology·Xingguo LiangHiroyuki Asanuma
Dec 10, 2008·Angewandte Chemie·Kemin WangWeihong Tan
Mar 26, 2009·Chemical Communications : Chem Comm·Li WuNaoki Sugimoto
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Youngmi KimWeihong Tan
Jun 9, 2009·Nano Letters·Huaizhi KangWeihong Tan
Feb 23, 2010·Angewandte Chemie·Mengguang ZhouHiroyuki Asanuma
Apr 19, 2011·Chemical Communications : Chem Comm·Chunming WangWeihong Tan

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Citations

Mar 13, 2014·Accounts of Chemical Research·Yukiko Kamiya, Hiroyuki Asanuma

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Methods Mentioned

BETA
irradiate
FRET
Fluorescence

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