Rev-erbα and the circadian transcriptional regulation of metabolism

Diabetes, Obesity & Metabolism
Z Gerhart-Hines, Mitchell A Lazar

Abstract

The circadian clock orchestrates the co-ordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiological function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biological networks and its relevance to organismal physiology.

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Jun 4, 2016·Molecular Cell·Jean-Pierre Etchegaray, Raul Mostoslavsky
Apr 6, 2017·Cell Metabolism·Saikumari Y KrishnaiahAalim M Weljie
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Mar 16, 2021·Frontiers in Endocrinology·Hélène Duez, Benoit Pourcet
Aug 9, 2021·Experimental Cell Research·Xuekai XiongKe Ma

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