Revaccination With Measles-Mumps-Rubella Vaccine and Infectious Disease Morbidity: A Danish Register-based Cohort Study

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Signe SørupChristine S Benn

Abstract

It has been hypothesized that revaccination with live vaccines is associated with reductions in off-target morbidity and mortality. We examined if revaccination with the live measles, mumps, and rubella vaccine (MMR) is associated with a lower rate of off-target infections. We performed a register-based nationwide cohort study that included 295559 children born in Denmark from April 2004 to December 2010. The cohort were followed from age 47 months (1 month before turning age 4 years, which is the recommended age of the second MMR [MMR-2]) until age 60 months. In Cox regression, we estimated adjusted incidence rate ratios (aIRRs) of antibiotic prescriptions and hospital admissions for any infection comparing MMR-2 as most recent vaccine with not having MMR-2 as the most recent vaccine. There was no association between MMR-2 and antibiotic prescriptions (aIRR, 1.01; 95% confidence interval [CI], 0.99-1.02). The aIRR for the association between MMR-2 and admissions for infection of any duration was 0.93 (95% CI, 0.88-0.98). For admissions for infection lasting 0 to 1 day, the aIRR was 0.97 (95% CI, 0.90-1.03) compared with the aIRR of 0.84 (95% CI, 0.74-0.95) for admissions for infection lasting 2 days or longer (test for equalit...Continue Reading

References

Jan 5, 2002·Health Policy·Karen Davis
Jun 4, 2002·Statistical Methods in Medical Research·Per Kragh Andersen, Niels Keiding
Jul 11, 2006·Immunological Reviews·Liisa K SelinRaymond M Welsh
Aug 4, 2011·Scandinavian Journal of Public Health·Lau Caspar Thygesen, Annette Kjær Ersbøll
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·John Sahl AndersenAllan Krasnik
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
Aug 4, 2011·Scandinavian Journal of Public Health·Vibeke M Jensen, Astrid W Rasmussen
Aug 4, 2011·Scandinavian Journal of Public Health·Mikkel Baadsgaard, Jarl Quitzau
Jan 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kim KristensenLone G Stensballe
Feb 8, 2013·The New England Journal of Medicine·Gary J Nabel
Apr 11, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K L FlanaganUNKNOWN Optimmunize Network
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Signe SørupHenrik Ravn
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter AabyChristine S Benn
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Anna GilLiisa K Selin
Jul 8, 2015·Journal of Leukocyte Biology·Bastiaan A BlokMihai G Netea
Sep 18, 2015·The Pediatric Infectious Disease Journal·Ane B FiskerPeter Aaby
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Apr 23, 2016·Science·Mihai G NeteaRamnik J Xavier
Apr 24, 2016·The Journal of Antimicrobial Chemotherapy·Rune AabenhusLars Bjerrum
Oct 16, 2016·BMJ : British Medical Journal·Julian P T HigginsArthur L Reingold
May 10, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara H BardenheierFrank DeStefano

❮ Previous
Next ❯

Citations

Feb 6, 2019·MMW Fortschritte der Medizin·Beate Schumacher
Apr 21, 2020·The Cochrane Database of Systematic Reviews·Carlo Di PietrantonjVittorio Demicheli
Jun 2, 2021·Molecular Medicine·Daniela Marín-HernándezNathaniel Hupert
Aug 13, 2021·Open Forum Infectious Diseases·Melanie Malave SanchezPoonam Mathur
Nov 23, 2021·The Cochrane Database of Systematic Reviews·Carlo Di PietrantonjVittorio Demicheli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.