Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome.

World Journal of Gastroenterology : WJG
A RivaAlberto Piperno

Abstract

To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPIII criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak's score and iron accumulation by Deugnier's score; steatosis was diagnosed when present in >or=5% of hepatocytes. According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiated two groups with a statistically significant different hepatic iron overload (P<0.0001). Patients with >or=2 metabolic alterations and steatosis had lower amount of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with <2 MS components and absence of steatosis. In our patients, the presence of >or2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overlo...Continue Reading

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Citations

Apr 29, 2010·Internal and Emergency Medicine·Clara Camaschella, Paolo Strati
Aug 31, 2012·The Journal of Biological Chemistry·Gunda MillonigSebastian Mueller
Mar 23, 2011·Metabolic Syndrome and Related Disorders·Ebubekir SenatesAyse Oya Kurdas Ovunc
Feb 6, 2009·World Journal of Gastroenterology : WJG·Alberto PipernoDomenico Girelli
Feb 9, 2016·Biochemical and Biophysical Research Communications·Xiaoqin LuoNanping Wang
Jan 31, 2015·Scandinavian Journal of Gastroenterology·Stefania GalimbertiAlberto Piperno
Mar 28, 2013·Expert Opinion on Medical Diagnostics·Alberto Piperno
Dec 7, 2010·European Journal of Clinical Investigation·Tomás MeroñoFernando Brites
Jul 8, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Paola TrombiniAlberto Piperno
Aug 15, 2012·Gene·Alejandro Del-Castillo-RuedaMaría-Josefa Morán-Jiménez
Jun 12, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alexandr A NikonorovAnatoly V Skalny
Jul 2, 2011·Journal of Hepatology·Paola DongiovanniLuca Valenti
Jun 15, 2015·Bioorganic & Medicinal Chemistry·Guadalupe García LiñaresAlicia Baldessari
Mar 22, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Raffaela RamettaLuca Valenti
Jan 5, 2017·American Journal of Hematology·Giulia RavasiAlberto Piperno
Jun 11, 2014·International Journal of STD & AIDS·Cristina López-CalderónJesús Santos
Sep 29, 2015·Journal of Clinical Apheresis·Calogero VetroFrancesco Di Raimondo
Feb 8, 2020·American Journal of Hematology·Giacomo MarchiDomenico Girelli
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Jun 23, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Sandra MilicSmiljana Ristic
May 22, 2020·Abdominal Radiology·Manuela França, João Gomes Carvalho
Jan 31, 2021·International Journal of Molecular Sciences·Sara PelucchiAlberto Piperno
Mar 14, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Raffaella MarianiAlberto Piperno

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