Revascularization in left ventricular dysfunction: an update

Current Opinion in Cardiology
Bobby YanagawaSubodh Verma

Abstract

The purpose of this article is to provide an overview of revascularization in patients with coronary artery disease (CAD) and left ventricular dysfunction (LVD). Patients with significant CAD and LVD are a high-risk patient population. They make up a minority of the cases from the largest, prospective coronary revascularization trials. The Surgical Treatment for Ischemic Heart Failure (STICH) Trial and its substudies are the most important and well cited in this field. The 10-year data from STICH showed that surgical revascularization was associated with lower all-cause mortality compared with medical therapy. Several smaller studies have confirmed that surgical revascularization carries a significant risk of short-term mortality but overall improved long-term outcomes in patients with LVD. Data from multiple observational studies further confirm that coronary artery bypass graft (CABG) is superior to percutaneous coronary revascularization for long-term survival and freedom from repeat revascularization in patients with LVD. We suggest that patients with LVD undergoing CABG should be considered for multiarterial grafting and that some patients may benefit from an off-pump procedure. Surgical revascularization confers a long-te...Continue Reading

References

May 16, 2003·The New England Journal of Medicine·Mariell Jessup, Susan Brozena
Jun 29, 2004·The American Journal of Cardiology·Steven P SedlisUNKNOWN Department of Veterans Affairs Cooperative Study #385, Angina With Extremely Serious Operative Mortality Evaluation (AWESOME
Aug 16, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ross T TsuyukiUNKNOWN APPROACH Investigators
Jan 4, 2008·Circulation·Paolo G CamiciOrnella E Rimoldi
Sep 22, 2009·The Annals of Thoracic Surgery·John D PuskasOmar M Lattouf
Apr 6, 2011·The New England Journal of Medicine·Eric J VelazquezUNKNOWN STICH Investigators
Apr 6, 2011·The New England Journal of Medicine·Robert O BonowUNKNOWN STICH Trial Investigators
Sep 23, 2011·The Annals of Thoracic Surgery·Omar A JarralThanos Athanasiou
Nov 6, 2012·The New England Journal of Medicine·Michael E FarkouhUNKNOWN FREEDOM Trial Investigators
Feb 21, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Siamak MohammadiPierre Voisine
Nov 7, 2015·Journal of the American College of Cardiology·E Marc JolicœurJohn G F Cleland
Jan 5, 2016·The Journal of Thoracic and Cardiovascular Surgery·Chikara UekiShinichi Takamoto
Apr 5, 2016·The New England Journal of Medicine·Eric J VelazquezUNKNOWN STICHES Investigators
Oct 25, 2016·The New England Journal of Medicine·André LamyUNKNOWN CORONARY Investigators
Aug 11, 2017·Current Opinion in Cardiology·Bobby YanagawaJohn D Puskas
Feb 24, 2018·Journal of the American College of Cardiology·Jeevan NagendranJayan Nagendran
Jul 3, 2018·The Journal of Thoracic and Cardiovascular Surgery·Alexander IribarneUNKNOWN Northern New England Cardiovascular Disease Study Group
Aug 31, 2018·European Heart Journal·Franz-Josef NeumannUNKNOWN ESC Scientific Document Group
Oct 30, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yangsin LeeShinichi Takamoto
Nov 15, 2018·Journal of the American College of Cardiology·Michael E FarkouhUNKNOWN FREEDOM Follow-On Study Investigators
Mar 6, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Tae Hee HongYoung Tak Lee

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