Revascularization Time in Liver Transplantation: Independent Prediction of Inferior Short- and Long-term Outcomes by Prolonged Graft Implantation

Transplantation
Bettina M BuchholzM Thamara P R Perera

Abstract

Strategies for successful transplantation are much needed in the era of organ shortage, and there has been a resurgence of interest on the impact of revascularization time (RT) on outcomes in liver transplantation (LT). All primary LT performed in Birmingham between 2009 and 2014 (n = 678) with portal reperfusion first were stratified according to RT (<44 minutes vs ≥44 minutes) and graft quality (standard liver graft [SLG], Donor Risk Index < 2.3 vs marginal liver graft [MLG], Donor Risk Index ≥ 2.3). Revascularization time of 44 minutes or longer resulted in significantly greater incidence of early allograft dysfunction (EAD) (29% vs 47%, P < 0.001), posttransplant acute kidney injury (AKI) (39% vs 60%, P < 0.001), and new-onset AKI (37% vs 56%, P < 0.001), along with poor long-term outcome (3-year graft survival 92% vs 83%, P = 0.001; 3-year patient survival 87% vs 79%, P = 0.004). On multivariable analysis, RT ≥ 44 was a significant independent predictor of EAD, renal dysfunction, and overall graft survival, but not patient survival. The cumulative effect of prolonged revascularization in marginal grafts (MLG) resulted in the worst transplant outcome compared with all other groups, which could be mitigated by rapid revascul...Continue Reading

References

Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N R BarshesJ A Goss
Jan 15, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D E SchaubelR M Merion
Aug 3, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M OlthoffJason D Christie
Jun 15, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y ZhaiJ W Kupiec-Weglinski
May 23, 2012·Journal of Hepatology·René AdamUNKNOWN European Liver and Intestine Transplant Association (ELITA)
Sep 11, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eugenia ParejaAgustín Lahoz
Dec 30, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jason M AliGavin J Pettigrew
Jan 6, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Annemarie WeissenbacherRobert Öllinger
Oct 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S J Knechtle, D L Sudan
Oct 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L HeylenJ Pirenne
Mar 31, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Joris J BlokUNKNOWN Eurotransplant Liver Intestine Advisory Committee
Sep 7, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L HeylenI Jochmans
Jan 4, 2018·Transplantation·Giovanni GirettiEphrem Salamé

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Citations

Jun 8, 2019·Expert Review of Gastroenterology & Hepatology·Marit KalisvaartAndrea Schlegel
Mar 25, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Line HeylenIna Jochmans
Jun 26, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Abbas Al-KurdShunji Nagai
Jun 20, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Angus HannM Thamara P R Perera
May 14, 2021·Transplantation·Hermien HartogM Thamara P R Perera

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