Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing

ELife
Arnaud PautratVeronique Coizet

Abstract

Pain is a prevalent symptom of Parkinson's disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli. We also show that nociception is altered following lesions of the STN, and characterize the role of the superior colliculus and the parabrachial nucleus in the transmission of nociceptive information to the STN, physiologically from both structures and anatomically in the case of the parabrachial nucleus. We show that STN nociceptive responses are abnormal in a rat model of PD, suggesting their dependence on the integrity of the nigrostriatal dopaminergic system. The STN-linked nociceptive network that we reveal is likely to be of considerable clinical importance in neurological diseases involving a dysfunction of the basal ganglia.

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Citations

Apr 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yiwen LuanChunyi Zhou
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marie BarbierPierre-Yves Risold
Mar 27, 2021·Neuron·Edgar Soria-GomezLuigi Bellocchio
Apr 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mickael DegouletYann Pelloux
May 27, 2021·Brain : a Journal of Neurology·Abteen MostofiErlick A C Pereira
Jun 3, 2021·Biomedicines·Myeong Seong BakSun Kwang Kim
Nov 28, 2019·Clinical Parkinsonism & Related Disorders·Yi-Cheng Tai, Chin-Hsien Lin
Apr 30, 2020·Stereotactic and Functional Neurosurgery·Tariq ParkerLuming Li

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