Revealing Shared and Distinct Genes Responding to JA and SA Signaling in Arabidopsis by Meta-Analysis

Frontiers in Plant Science
Nailou ZhangZhijin Fan

Abstract

Plant resistance against biotrophic and necrotrophic pathogens is mediated by mutually synergistic and antagonistic effects of salicylic acid (SA) and jasmonic acid (JA) signals. However, the unique and shared genes responding to the defense mediated by JA/SA signals were largely unclear. To reveal discrete, synergistic and antagonistic JA/SA responsive genes in Arabidopsis thaliana, Meta-Analysis was employed with 257 publicly available Arabidopsis thaliana RNA-Seq gene expression profiles following treatment of mock, JA or SA analogs. JA/SA signalings were found to co-induce broad-spectrum disease-response genes, co-repress the genes related to photosynthesis, auxin, and gibberellin, and reallocate resources of growth toward defense. JA might attenuate SA induced immune response by inhibiting the expression of resistance genes and receptor-like proteins/kinases. Strikingly, co-expression network analysis revealed that JA/SA uniquely regulated genes showing highly coordinated co-expression only in their respective treatment. Using principal component analysis, and hierarchical cluster analysis, JA/SA analogs were segregated into separate entities based on the global differential expression matrix rather than the expression mat...Continue Reading

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Citations

May 22, 2021·Journal of Experimental Botany·Athanasios Dalakouras, Dimitrios Vlachostergios
Jul 3, 2021·International Journal of Molecular Sciences·Khalid AnwarAshwani Pareek

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Datasets Mentioned

BETA
PRJNA270886
PRJNA354369
PRJNA303108
PRJNA394842
PRJNA318266
PRJNA354373
PRJNA276445
PRJNA315516
PRJNA336058
GPL198

Methods Mentioned

BETA
PCA
RNA-Seq
Profiler

Software Mentioned

pathClass
R package MetaDE
Ensembl
Analysis
sva
package
limma
- Analysis
Meta
MetaDE R package

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