Revealing the anti-HRP epitope in Drosophila and Caenorhabditis.

Glycoconjugate Journal
Katharina PaschingerIain B H Wilson

Abstract

Antibodies are very often used as specific cell and/or tissue markers. An example of this is anti-horseradish peroxidase (HRP), an antibody raised against a plant glycoprotein, which was shown some twenty-five years ago to specifically stain neural tissue in an animal, Drosophila melanogaster. This peculiar finding was later expanded to other invertebrate species including Caenorhabditis elegans, which were also shown to bear anti-HRP epitopes. Initial experiments indicated that the epitopes recognised by anti-HRP in invertebrates are of carbohydrate nature. Indeed, more recent experiments have characterised relevant core alpha1-3-fucosylated N-glycan structures that act as epitopes in various model and parasitic organisms. Moreover, a number of enzymes required for the synthesis of such structures have been identified. Over the years, medically-relevant roles of these structures have become apparent as regards allergenicity and immunoregulation. Although major advances have been made in understanding of the underlying mechanisms and structures related to the anti-HRP epitope, the in vivo role of the relevant epitopes in neural and other tissues is yet to be resolved. Current understanding of the anti-HRP epitopes synthesis and...Continue Reading

References

Aug 1, 1992·European Journal of Biochemistry·E StaudacherL März
Oct 10, 1991·Biochimica Et Biophysica Acta·P J WilliamsD R Roberts
Aug 1, 1989·The Journal of Allergy and Clinical Immunology·V L KoshteR C Aalberse
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P M SnowC S Goodman
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L Y Jan, Y N Jan
Jun 21, 1996·Carbohydrate Research·B Y YangR Montgomery
Apr 4, 1997·The Journal of Biological Chemistry·T A HsuM J Betenbaugh
Feb 6, 1998·Analytical Biochemistry·N TakahashiY C Lee
Jul 2, 1998·Journal of Neurochemistry·B SunP M Salvaterra
Jul 14, 1998·Molecular and Biochemical Parasitology·S M HaslamA Dell
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A AdoutteR de Rosa
Oct 31, 2001·Development Genes and Evolution·A HaaseG Bicker
Feb 16, 2002·European Journal of Biochemistry·Philippe SaudanEric Kubli
Apr 2, 2002·Glycoconjugate Journal·K Fötisch, S Vieths
Apr 19, 2002·The Journal of Biological Chemistry·Samuel BouyainKurt Drickamer
Oct 31, 2002·Development·Raphaelle DubruilleBénédicte Durand
Jun 6, 2003·European Journal of Biochemistry·Noriko TakahashiKoichi Kato
Jan 31, 2004·Phytochemistry·Nigel C Veitch
Mar 20, 2004·European Journal of Biochemistry·Martin GutterniggErika Staudacher
Sep 15, 2004·The Journal of Biological Chemistry·Katharina PaschingerIain B H Wilson
Dec 18, 2004·Glycobiology·Katharina PaschingerIain B H Wilson
Nov 30, 2005·The Journal of Biological Chemistry·Dubravko RendicGustáv Fabini
Mar 9, 2006·The Journal of Biological Chemistry·Mohan SarkarGabrielle L Boulianne

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Citations

May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mohan SarkarGabrielle L Boulianne
Jun 30, 2012·The Journal of Biological Chemistry·Christoph GeislerDonald L Jarvis
Nov 10, 2012·The Journal of Biological Chemistry·Birgit SchillerIain B H Wilson
Feb 2, 2011·The Journal of General Physiology·Huifang MaIrwin B Levitan
Oct 11, 2011·Glycobiology·Katharina PaschingerIain B H Wilson
Jun 22, 2010·Development Genes and Evolution·Harper C VansteenhouseBirgit Zipser
Dec 10, 2015·Analytical and Bioanalytical Chemistry·Iain B H Wilson, Katharina Paschinger
Nov 2, 2015·Applied Microbiology and Biotechnology·Jerica SabotičMarkus Künzler
Jan 27, 2011·Biochemical Society Transactions·Karin Hoffmann-SommergruberIain B H Wilson
Aug 24, 2011·Journal of the American Chemical Society·Sonia SernaNiels-Christian Reichardt
May 9, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Markus Künzler
Aug 15, 2018·Molecular & Cellular Proteomics : MCP·Alba HykollariKatharina Paschinger
Mar 7, 2020·Bioengineered·Khalisanni KhalidLai Chin Wei
May 3, 2019·Parasitology·Katharina Paschinger, Iain B H Wilson
Nov 9, 2010·Fly·Harry Schachter, Gabrielle Boulianne
Aug 10, 2019·Biochimica Et Biophysica Acta. General Subjects·Alba HykollariKatharina Paschinger
Nov 1, 2018·Molecular & Cellular Proteomics : MCP·Alba HykollariKatharina Paschinger
Nov 15, 2013·Development·William ParkinsonKendal Broadie
Jun 12, 2009·Carbohydrate Research·Harry Schachter
Mar 1, 2012·Biochimica Et Biophysica Acta·Nicolai BovinMargaret Huflejt

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