Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream.

Scientific Reports
Delaram AhmadiM Jayne Lawrence

Abstract

Creams are multi-component semi-solid emulsions that find widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, and they also feature prominently in veterinary preparations and processed foodstuffs. The internal architectures of these systems, however, have to date been inferred largely through macroscopic and/or indirect experimental observations and so they are not well-characterized at the molecular level. Moreover, while their long-term stability and shelf-life, and their aesthetics and functional utility are critically dependent upon their molecular structure, there is no real understanding yet of the structural mechanisms that underlie the potential destabilizing effects of additives like drugs, anti-oxidants or preservatives, and no structure-based rationale to guide product formulation. In the research reported here we sought to address these deficiencies, making particular use of small-angle neutron scattering and exploiting the device of H/D contrast variation, with complementary studies also performed using bright-field and polarised light microscopy, small-angle and wide-angle X-ray scattering, and steady-state shear rheology measurements. Through the convolved findings from...Continue Reading

References

Aug 24, 1984·Pharmaceutisch Weekblad. Scientific Edition·H E Junginger
Jun 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Eugenio CaponettiLucia Pedone
Dec 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ali ZarbakhshJohn R P Webster
Mar 28, 2008·Expert Opinion on Investigational Drugs·Jeanette Jacobsson Sundberg, Jan Faergemann
Dec 3, 2013·BioMed Research International·Sara RaposoHelena M Ribeiro
Aug 12, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Mario CampanaAli Zarbakhsh
Jul 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jun Bae LeeB Moon Kim
Jul 18, 2015·Soft Matter·Alireza Bahramian, Ali Zarbakhsh
Jan 16, 2016·Journal of Molecular Modeling·Jose G Méndez-Bermúdez, Hector Dominguez
Jun 14, 2016·Indian Journal of Dermatology·Anisha SethiM L Gambhir
May 28, 2019·BMC Veterinary Research·Milena TreschMichael Walkenhorst

❮ Previous
Next ❯

Citations

Sep 17, 2020·Pharmaceutics·Delaram AhmadiM Jayne Lawrence
Nov 27, 2020·Journal of Colloid and Interface Science·Delaram AhmadiM Jayne Lawrence

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
light microscopy
small-angle neutron scattering
SANS
rheology
neutron scattering
3 hybrid

Software Mentioned

LAMP
SASVIEW
FISH
SANS2d
LoQ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.