Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI

Scientific Reports
Jerome J MallerStuart M Grieve

Abstract

The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n = 94; 391-directions). Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. The strongest individual connection was to the ipsilateral thalamus. There was a strong age dependence of hippocampal connectivity to medial occipital regions. Overall, our results concur with preclinical and ex-vivo data, confirming that meaningful in vivo characterisation of hippocampal connections is possible in an individual. Our findings extend the collective knowledge of hippocampal anatomy, highlighting the importance of the spinal-limbic pathway and the striking lack of hippocampal connectivity with motor and sensory cortices.

References

Jun 25, 2003·Brain : a Journal of Neurology·Marco CataniDominic H Ffytche
Nov 19, 2003·The European Journal of Neuroscience·Gary G BerntsonJohn T Cacioppo
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Derek K Jones
Dec 14, 2004·NeuroImage·Belinda J LiddellLeanne M Williams
Jun 25, 2005·Neuroscience·M CastleA D Loewy
Mar 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P G BatchelorA Connelly
Jul 3, 2007·Brain Research Reviews·William D Willis
May 6, 2008·Neurobiology of Aging·D H SalatH D Rosas
May 5, 2009·PLoS Computational Biology·Damien A FairSteven E Petersen
Jun 23, 2009·Genome Research·Martin KrzywinskiMarco A Marra
Jun 26, 2010·Frontiers in Systems Neuroscience·Lucina Q UddinVinod Menon
Feb 25, 2011·Neuroreport·Cristina GranzieraGunnar Krueger
Mar 1, 2011·NeuroImage·Fernando CalamanteAlan Connelly
Apr 26, 2011·Developmental Cognitive Neuroscience·Melissa P Lopez-LarsonDeborah Yurgelun-Todd
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
Sep 13, 2014·Cellular and Molecular Life Sciences : CMLS·Oren Schuldiner, Avraham Yaron
Nov 5, 2015·Brain Connectivity·Brian L EdlowHannah C Kinney
Feb 24, 2016·Brain Structure & Function·María Guadalupe García-GomarLuis Concha
May 18, 2016·World Neurosurgery·Serhat BaydinAlbert L Rhoton
Jul 19, 2016·NeuroImage·Juan Eugenio IglesiasUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 26, 2017·Brain and Neuroscience Advances·Emma J BubbJohn P Aggleton
Nov 9, 2017·Nature Communications·Klaus H Maier-HeinMaxime Descoteaux

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Citations

Aug 28, 2020·Brain : a Journal of Neurology·Anna PlachtiSarah Genon
Jul 7, 2020·Frontiers in Human Neuroscience·Masaki TanakaSeiki Konishi
Jan 23, 2021·Neuron·Francesca RocchiChristopher I Petkov
Jan 8, 2021·World Neurosurgery·Yueh-Hsin LinMichael E Sughrue
Jan 19, 2021·NeuroImage. Clinical·Sarah C HellewellStuart M Grieve
Apr 8, 2021·Communications Biology·Tomomi Mizuochi-EndoKimihiro Nakamura
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Josh King-RobsonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson
Aug 13, 2021·Frontiers in Human Neuroscience·Rika HaraguchiYoshihito Shigihara
Oct 1, 2021·Journal of Magnetic Resonance Imaging : JMRI·Liangyou LiuSong Gao
May 27, 2020·NeuroImage·Shahrzad Kharabian MasoulehSarah Genon

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Methods Mentioned

BETA
dissection

Software Mentioned

FreeSurfer
FMRIB
DV25
MRtrix3
Circos
CDCP
Automated Segmentation Tool ( FAST

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