Revealing the Immunogenic Risk of Polymers

Angewandte Chemie
Bowen LiShaoyi Jiang

Abstract

Poly(ethylene glycol) (PEG) conjugation has been the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. PEG polymer does become immunogenic once attached to proteins, evoking PEG-specific antibody (Ab) responses. The anti-PEG Abs could cause PEGylated biologic treatments to fail and even result in lethal adverse reactions. Thus the zwitterionic poly(carboxybetaine) (PCB) has been introduced as a PEG substitute for protein modification. Addressed herein is anti-polymer Ab induction by conjugating PEG and PCB polymers to a series of carrier proteins with escalating immunogenicity. Results indicate that titers of PEG-specific Abs were quantitatively correlated to the immunogenicity of carrier proteins, whereas the generation of PCB-specific Abs was minimal and insensitive to increased protein immunogenicity. This work provides insight into the immunological properties of PEG and PCB and has far-reaching implications for the development of polymer-protein conjugates.

References

Jan 1, 1983·International Archives of Allergy and Applied Immunology·A W Richter, E Akerblom
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Sep 24, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Jie ZhengShaoyi Jiang
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Per Magne UelandSteinar Hustad
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
Apr 20, 2006·Amino Acids·M Werle, A Bernkop-Schnürch
Sep 11, 2007·Advanced Drug Delivery Reviews·Merry R ShermanFernando Perez-Ruiz
Jan 14, 2010·Biotechnology Journal·Simona JevsevarVladka Gaberc Porekar
Feb 16, 2012·Bioconjugate Chemistry·Merry R ShermanMark G P Saifer
Jun 30, 2012·Nature Reviews. Drug Discovery·Steven A BerkowitzGraham B Jones
Aug 31, 2012·Expert Opinion on Drug Delivery·Ricardo P GarayPascal Richette
Dec 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kouichi ShiraishiMasayuki Yokoyama
May 15, 2013·Nature Biotechnology·Lei ZhangShaoyi Jiang
May 16, 2013·Pharmaceutical Research·Huub SchellekensVera Brinks
Jun 4, 2013·Biological & Pharmaceutical Bulletin·Tatsuhiro Ishida, Hiroshi Kiwada
Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Atul KolateAmbikanandan Misra
Jun 1, 2011·Therapeutic Advances in Drug Safety·Michael G Tovey, Christophe Lallemand
Aug 12, 2014·Nature Reviews. Drug Discovery·Samir MitragotriRobert Langer
Sep 11, 2014·Drug Discovery Today·Johan J F VerhoefHuub Schellekens
Nov 5, 2014·Advanced Materials·Qing Shao, Shaoyi Jiang
Feb 25, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qi Yang, Samuel K Lai
Jul 15, 2015·ACS Applied Materials & Interfaces·Chuan LengZhan Chen
Sep 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Peng ZhangShaoyi Jiang
Feb 13, 2016·Frontiers in Immunology·Murli Krishna, Steven G Nadler
Jul 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peng ZhangShaoyi Jiang
Feb 13, 2018·Angewandte Chemie·Bowen LiShaoyi Jiang
Feb 20, 2018·Advanced Materials·Bowen LiShaoyi Jiang

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Citations

Jan 23, 2019·Advanced Healthcare Materials·Eun Sook LeeJae Hyung Park
Jul 17, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Marina A Dobrovolskaia, Mark Bathe
Sep 1, 2020·Angewandte Chemie·Zhefan YuanShaoyi Jiang
Jan 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arnau BioscaXavier Fernàndez-Busquets
Dec 18, 2020·Advanced Drug Delivery Reviews·Yong Liu, Lichen Yin
Jun 9, 2020·Bioconjugate Chemistry·Caroline TsaoShaoyi Jiang
Mar 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Caroline TsaoShaoyi Jiang
Jul 12, 2019·Advanced Drug Delivery Reviews·Raziye MohammadpourHamidreza Ghandehari
May 4, 2021·Advanced Materials·Chihyeong WonTaeyoon Lee
Aug 17, 2020·Current Opinion in Biotechnology·Zhiyuan FanHao Cheng
Aug 29, 2020·Journal of Agricultural and Food Chemistry·Kai WenZhanhui Wang
Nov 7, 2018·Bioconjugate Chemistry·David J PeelerSuzie H Pun
Mar 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Peng WangXiangyang Shi
Sep 29, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaojie LinShaoyi Jiang
Oct 10, 2021·Advanced Healthcare Materials·Yeonsu JeongHyung Joon Cha

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