Revealing the metabolic characteristics of human embryonic stem cells by genome-scale metabolic modeling

FEBS Letters
Yangzhige HeFuchu He

Abstract

Embryonic stem cells (ESCs) are characterized by a dual capacity, self-renewal and pluripotency, which can be regulated by metabolism. A better understanding of ESC metabolism and regulatory mechanisms is pivotal for research into development, ageing, and cancer treatment. However, a systematic and comprehensive delineation of human ESC metabolism is still lacking. Here, we reconstructed the first genome-scale metabolic model (GEM) of human ESCs (hESCs). By GEM simulation and analyses, hESC global metabolic characteristics including essential metabolites and network motifs were identified. Potential metabolic subsystems responsible for self-renewal and pluripotency were also identified by analyses and experiments. This first GEM of hESCs provides a novel view and resource for stem cell metabolism research and will contribute to the elucidation of their metabolic characteristics.

References

Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Feb 4, 2006·Bioinformatics·Sebastian Wernicke, Florian Rasche
Aug 22, 2006·Biochemical and Biophysical Research Communications·Young Min ChoHong Kyu Lee
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalie C DuarteBernhard Ø Palsson
Jul 10, 2008·Nature Biotechnology·Matthew A HannahLothar Willmitzer
Aug 20, 2008·Nature Biotechnology·Tomer ShlomiEytan Ruppin
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Feb 19, 2010·Experimental & Molecular Medicine·Ae-Ri JiYoung Min Choi
May 4, 2010·Nature Chemical Biology·Oscar YanesGary Siuzdak
Mar 1, 2012·Nature Reviews. Microbiology·Nathan E LewisBernhard O Palsson
Nov 6, 2012·Cell Stem Cell·Clifford D L FolmesAndre Terzic
Jan 5, 2013·Molecular BioSystems·Erin R ShellmanSantiago Schnell
Mar 5, 2013·Nature Biotechnology·Ines ThieleBernhard Ø Palsson
May 30, 2013·Development·Ng Shyh-ChangLewis C Cantley
Aug 10, 2013·BMC Systems Biology·Ali EbrahimDaniel R Hyduke
Mar 7, 2014·The EMBO Journal·Brad LackfordYongsheng Shi
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Keisuke Ito, Toshio Suda
Dec 9, 2014·Nucleus·Ana CurinhaAlexandra Moreira
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Dec 8, 2015·Cell Stem Cell·James G RyallVittorio Sartorelli
Dec 15, 2015·Stem Cell Research & Therapy·Laia TolosaAnne Dubart-Kupperschmitt
Apr 28, 2016·Cell Reports·Gang ZhouJohn P Cooke
Dec 27, 2016·Stem Cell Reports·Cristina D'AnielloGabriella Minchiotti
Oct 22, 2017·Free Radical Biology & Medicine·Cheng-Kai WangJean Lu

❮ Previous
Next ❯

Citations

Dec 31, 2019·Stem Cells International·Jilan LiuFeng Jin
Oct 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evelyn RamplerGunda Koellensperger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.