Mar 24, 2019

Revealing virulence potential of clinical and environmental Aspergillus fumigatus isolates using Whole-genome sequencing

BioRxiv : the Preprint Server for Biology
F. Puértolas-BalintS. García-Cobos

Abstract

Aspergillus fumigatus is an opportunistic airborne pathogen and one of the most common causative agents of human fungal infections. A restricted number of virulence factors have been described but none of them lead to a differentiation of the virulence level among different strains. In this study, we analyzed the whole-genome sequence of a set of A. fumigatus isolates from clinical and environmental origin to compare their genomes and to determine their virulence profiles. For this purpose, a database containing 244 genes known to be associated with virulence was built. The genes were classified according to their biological function into factors involved in thermotolerance, resistance to immune responses, cell wall structure, toxins and secondary metabolites, allergens, nutrient uptake and signaling and regulation. No difference in virulence profiles was found between clinical isolates causing an infection and a colonizing clinical isolate, nor between isolates from clinical and environmental origin. We observed the presence of genetic repetitive elements located next to virulence related gene groups, which could potentially influence their regulation. In conclusion, our genomic analysis reveals that A. fumigatus , independent...Continue Reading

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Mentioned in this Paper

Thermotolerance
Study
Immune Response
Treatment Protocols
Genome
Genes
Regulation of Biological Process
Toxin
Environment
Uptake

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