Revelation of Brugada electrocardiographic pattern during a febrile state

International Journal of Cardiology
Salvatore PatanèSanta Alessandra Villari

Abstract

The prevalence of the Brugada-type ECG and its natural history are still unclear. The Brugada syndrome is usually identified by a characteristic Brugada-type ECG that consists of ST elevation of a coved type in the precordial leads V1 to V3 and ventricular fibrillation that can lead to sudden cardiac death, although affected individuals may have a normal ECG. Mutations in the cardiac sodium channel gene SCN5A, which encodes the alpha-subunit of the human cardiac voltage-dependent Na+ channel (Na(v)1.5), are identified in 15-30% of patients with Brugada syndrome. Most SCN5A mutations lead to a 'loss-of-function' phenotype, reducing the Na+ current during the early phases of the action potential. Several nongenetic factors have been mentioned in the literature as possible inductors of the ECG pattern resembling Brugada syndrome. As such, a Brugada-type ECG may appear in some patients during febrile states and in those who are under the influence of cocaine and pharmaceutical drugs that have a sodium channel-blocking effect. It has been also reported that chest pain and ST elevation Brugada pattern occur during febrile states. We present a case of revelation of Brugada pattern in a 61-year-old Italian man complaining of pain in th...Continue Reading

References

Feb 13, 2007·International Journal of Cardiology·Marcos DaccarettChristian Machado
Sep 1, 2007·International Journal of Cardiology·Colleen E Clancy, Xander H T Wehrens
Nov 27, 2007·International Journal of Cardiology·Amrut V AmbardekarMori J Krantz
Dec 7, 2007·International Journal of Cardiology·Mark M GallagherFrancesco Romeo
Apr 9, 2008·Circulation·M Juhani JunttilaRamon Brugada
Dec 3, 2008·International Journal of Cardiology·Andrew J S Coats

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Citations

Feb 8, 2011·International Journal of Cardiology·Fiorella SalernoPhilippe Chevalier
Apr 13, 2010·International Journal of Cardiology·Andrea Duarte DoetzerSalmo Raskin
Nov 20, 2012·International Journal of Cardiology·G CoppolaS Novo
Mar 26, 2013·Journal of Electrocardiology·Marta NorisMiquel Fiol
Jul 14, 2019·BMJ Case Reports·Hassan AbbasGanesh Gajanan

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