Reversal by serotonergic agents of reserpine-induced hyperalgesia in rats

European Journal of Pharmacology
Shrinivas K Kulkarni, R K Robert

Abstract

Reserpine (4 mg/kg) induced a time-dependent reduction in pain threshold (hyperalgesia) as observed by the tail-flick technique in rats. Serotonin, its precursor 5-hydroxytryptophan or the receptor agonist, quipazine reversed the reserpine-induced hyperalgesia. On the other hand, piribedil, amantadine, imipramine or desipramine treatment failed to reverse the reserpine-induced hyperalgesia. Similarly, intracerebroventricular administration of dopamine or noradrenaline also had no effect on reserpine-induced hyperalgesia. These observations not only suggested a role of serotonin in hyperalgesia but also that reserpine hyperalgesia is suitable for selective study of serotonin-mediated responses in rats.

References

Oct 1, 1978·The Journal of Pharmacy and Pharmacology·J A Garcia-SevillaA Carlsson
Nov 1, 1973·European Journal of Pharmacology·R RodríguezR R Drucker-Colín
Oct 15, 1960·Experientia·E COSTAL VALZELLI
Mar 1, 1964·The Journal of Pharmacy and Pharmacology·M MEDAKOVIC, B BANIC

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