PMID: 697762Jul 15, 1978Paper

Reversal by triton WR-1339 of ethynyloestradiol-induced hepatic cholesterol esterification

The Biochemical Journal
R A DavisF Kern

Abstract

RATS TREATED WITH ETHYNYLOESTRADIOL HAVE MARKED HYPOLIPIDAEMIA: serum cholesterol is decreased to 5%, triacylglycerol to 10% and phospholipid to 70% of control concentrations. Loss of serum cholesterol follows an exponential decay, with a half-life of 1.13+/-0.09 days. After 4 days of treatment, serum cholesterol concentrations remain relatively constant (ranging from 1 to 20mg/100ml) for at least 30 days. There is a concomitant 20-fold decrease in the d<1.21 fraction of serum proteins and a similar decrease in serum apolipoproteins as measured by sodium dodecyl sulphate/10%-polyacrylamide-gel electrophoresis. The activity of hepatic microsomal acyl-CoA-cholesterol O-acetyltransferase (EC 2.3.1.26) was significantly increased by ethynyloestradiol treatment (P<0.05). This activation caused hepatic cholesteryl esters containing mainly C(18:1) fatty acids to increase linearly as serum cholesterol concentrations decreased (r=0.9675, P<0.001). Triton WR-1339, a non-ionic detergent that inhibits lipoprotein catabolism, was used to estimate hepatic lipid secretion by measuring the increment in serum lipids after its administration. At 15h after Triton WR-1339 administration, serum cholesterol concentrations were increased equally in b...Continue Reading

Citations

May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F O NerviB O Ronco
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R L MosesR A Davis
Oct 8, 1997·The American Journal of Physiology·C A HornickJ G DeLamatre
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L AccatinoC S Koenig
Jul 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·A F Burton, F H Anderson
Nov 1, 1981·The American Journal of Physiology·R S Kushwaha, W R Hazzard
Mar 17, 1992·Biochemical Pharmacology·J V RodriguezC Tiribelli
Jan 1, 1989·Pharmacology & Therapeutics·R A DavisL H Junker
Aug 21, 1986·Biochimica Et Biophysica Acta·S M SchwarzM Mone
Dec 5, 1986·Biochimica Et Biophysica Acta·G F BarnardA D Cooper
Jul 24, 1981·Biochimica Et Biophysica Acta·R A DavisP S Roheim
May 16, 1983·Biochimica Et Biophysica Acta·A H Lichtenstein, P Brecher
Jan 1, 1979·Progress in Lipid Research·A A SpectorT L Kaduce
Apr 1, 1981·Metabolism: Clinical and Experimental·R S Kushwaha, W R Hazzard

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