PMID: 6538253Feb 13, 1984Paper

Reversal of amphetamine-induced circling preference in trained circling rats

Life Sciences
B K Yamamoto, C R Freed

Abstract

Others have shown that amphetamine given to normal rats causes turning in a particular, preferred direction in most animals. We have studied the effect of training on amphetamine-induced behavioral and biochemical asymmetries in male Sprague-Dawley rats. Water deprived animals were trained to circle either in the same or opposite direction to their intrinsic bias using a sucrose water reward. Acquisition of the learned circling behavior was independent of turning preference and all animals were able to make the operant association. After training, animals given amphetamine turned in the trained direction regardless of their previous circling preference. Amphetamine-induced circling also led to increased dopamine concentrations in caudate contralateral to the trained circling direction. Therefore, intrinsic striatal lateralization is not resistant to behavioral modification and both the behavioral and biochemical asymmetries can be reversed by circling training.

References

Dec 1, 1978·Neuropharmacology·L R Nelson, G Ellison
Jan 20, 1978·Brain Research·B ZimmerbergS D Glick
Sep 15, 1976·Biochemical Pharmacology·T J MantleN J Garrett
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D S Segal, A J Mandell
Aug 16, 1974·Science·B ZimmerbergT P Jerussi
Apr 1, 1974·Neuropharmacology·T P Jerussi, S D Glick
Jun 21, 1982·Life Sciences·B K YamamotoC R Freed

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Citations

Jun 1, 1990·Physiology & Behavior·J B RichardsC R Freed
Jun 1, 1990·Pharmacology, Biochemistry, and Behavior·J B RichardsC R Freed
Feb 1, 1986·Brain Research Bulletin·R A Wise, L J Holmes
Jun 27, 2014·Frontiers in Systems Neuroscience·Ilana Molochnikov, Dana Cohen
Jun 29, 2016·Neuroscience and Biobehavioral Reviews·A K M Rezaul KarimLora T Likova

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