PMID: 11922912Mar 30, 2002Paper

Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing

Cardiovascular Research
Sébastien BonnetJean-Pierre Savineau

Abstract

Chronic hypoxia (CH) induces selective pulmonary hypertension which is accompanied by structural and functional alterations in the pulmonary vasculature. Little information is available on the regression of CH-induced functional alterations of pulmonary wall. In the present work, we investigated the reversal of CH-induced pulmonary hypertension with a special focus on alterations in the electrophysiological properties of pulmonary artery smooth muscle cells (PAMCs) after normoxia recovery. Rats were exposed to a hypobaric environment for 3 weeks (CH rats) and then subjected to a normoxic environment for 3 weeks (normoxia-recovery group) and compared with rats maintained in a normoxic environment (control rats). Electrophysiological properties of PAMCs were studied using conventional microelectrodes and patch-clamp technique. CH rats exhibited a threefold increase in pulmonary blood pressure compared to control rats and this increase was fully reversed following 3 weeks of normoxia. PAMCs from CH rats were depolarised (about 20 mV), had an elevated calcium concentration and exhibited a hypersensitivity to 4-aminopyridine (4-AP) of membrane potential as well as the tone of arterial rings compared with tissues from control rats. W...Continue Reading

Citations

Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Simon Tual-ChalotM Carmen Martinez
Mar 7, 2006·BMC Anesthesiology·Nazinigouba OuédraogoEtienne Roux
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sébastien BonnetEtienne-Emile Baulieu
Jul 14, 2014·Cardiovascular Research·Marc ChevalierJean-François Quignard
Aug 12, 2014·Pharmacology & Therapeutics·Andrea OlschewskiHorst Olschewski
Dec 28, 2010·Canadian Journal of Physiology and Pharmacology·Karine Nouette-GaulainFrançois Sztark
May 25, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Olivier PauvertJean-Pierre Savineau
Mar 15, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Su Jung ParkSung Joon Kim
Nov 4, 2006·Journal of Magnetic Resonance Imaging : JMRI·Mathieu LederlinElodie Parzy
Oct 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·M HintonS Dakshinamurti
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Oct 15, 2011·American Journal of Physiology. Cell Physiology·Hae Young YooSung Joon Kim
May 21, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jun WanJason X-J Yuan
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pierre BonnetVéronique Eder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.