Reversal of fluorosis in children

Acta Paediatrica Japonica; Overseas Edition
S K GuptaA Gupta

Abstract

Large populations consume fluoride-contaminated water, especially in developing countries. The toxic effects of fluorosis take three forms: clinical, skeletal and dental. Research thus far indicates that the manifestations of fluorosis are irreversible. However, it has been observed that the ingestion of calcium, vitamin C or vitamin D, individually, is effective in protection from fluoride toxicity to a certain extent. Therefore, a double blind control trial was conducted to examine the effect of a combination of calcium, vitamin D3 and ascorbic acid supplementation in fluorosis-affected children. In the present study, 25 children were selected from an area consuming water containing 4.5 p.p.m. of fluoride, All the children were in the age group 6-12 years and weighed 18-30 kg. They were graded for clinical, radiological and dental fluorosis and relevant biochemical parameters. Grade I skeletal fluorosis and all grades of the manifestation of dental and clinical fluorosis were observed. The children were given ascorbic acid, calcium and vitamin D3 well below the toxic dosages in a double blind manner using lactose as a placebo. Follow up revealed a significant improvement in dental, clinical and skeletal fluorosis and relevant...Continue Reading

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Citations

Apr 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Sunil Kumar GuptaH P Trivedi
Oct 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Vinita AilaniKapil Gupta
Nov 7, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J Verma, D M Guna Sherlin
May 12, 2001·Neurotoxicology and Teratology·D M Guna Sherlin, R J Verma
Jan 9, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael P WhyteGary M Whitford
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jodi L SkilesMonica L Hulbert
Feb 24, 2001·Human & Experimental Toxicology·D M Guna Sherlin, R J Verma
Apr 9, 2002·Human & Experimental Toxicology·R J Verma, D M Sherlin
Jan 31, 2020·Environmental Geochemistry and Health·Sunil J Wimalawansa
Jul 22, 2020·Current Opinion in Pediatrics·Nipith CharoenngamMichael F Holick
Oct 2, 2013·Toxicology and Industrial Health·Raghu JettiRao C Mallikarjuna
Oct 2, 2021·The Science of the Total Environment·Yogendra Singh SolankiPushkar Shukla

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