PMID: 9184806May 1, 1997Paper

Reversal of gastric somatostatin receptor inhibition by Helicobacter pylori lipopolysaccharide with ebrotidine and sulglycotide

General Pharmacology
J PiotrowskiB L Slomiany

Abstract

1. Among the consequences of H. pylori infection is an increase in gastric acid secretion due to the impairement in feedback inhibition by somatostatin. Here, we show that lipopolysaccharide from H. pylori inhibits the binding of somatostatin to gastric mucosal receptor, and that antiulcer agents, ebrotidine and sulglycotide, are capable of countering this effect. 2. The somatostatin receptor was prepared from the solubilized gastric mucosal epithelial cell membranes by affinity chromatography on Affi-Gel-bound [D-Tryp8] SRIF-14 and used in the binding assays for 125I-labeled somatostatin in the presence of H. pylori lipopolysaccharide and antiulcer agents. 3. The assays revealed a dose-dependent inhibition in the receptor-somatostatin binding by the lipopolysaccharide which reached a maximum of 94.1%. The effect of H. pylori lipopolysaccharide was countered by ebrotidine and sulglycotide, which at their optimal doses produced 94.9% and 84% restoration in somatostatin-receptor binding, respectively. 4. The results demonstrate that the antiulcer agents, ebrotidine and sulglycotide, possess the ability to counteract the H. pylori interference with somatostatin regulatory effect on gastric acid secretion.

References

Jul 1, 1992·General Pharmacology·B L SlomianyA Slomiany
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H T HeT Reisine
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal
Sep 1, 1994·General Pharmacology·B L SlomianyA Slomiany
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·B L SlomianyA Slomiany

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Citations

Jul 21, 2005·Journal of Bacteriology·Koji HiratsukaEleonora Altman
Jun 8, 2002·Biochemical and Biophysical Research Communications·Bronislaw L Slomiany, Amalia Slomiany
Nov 28, 2006·Nature Reviews. Cancer·Susan A WatsonArjun Takhar

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