PMID: 7295860Sep 1, 1981Paper

Reversal of glucose-induced hyperkalemia by sodium restriction in normaldosteronemic diabetes: evidence for elevated mineralocorticoid threshold

Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
J P Radó

Abstract

Acute glucose loading studies were performed on seven diabetic patients and 18 control subjects. In two normaldosteronemic insulin-dependent diabetic patients during high sodium intake and insulin withdrawal infusion of hypertonic glucose induced a paradoxical elevation of serum potassium levels, while no such abnormalities were found in two other diabetics despite of lower plasma aldosterone levels. Paradoxical glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g of glucose orally to further three patients with normaldosteronemic diabetes in whom a complete reversal of PGIH was obtained l glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g of glucose orally to further three patients with normaldosteronemic diabetes in whom a complete reversal of PGIH was obtained l glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g...Continue Reading

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Blood Glucose
Diabetes Mellitus
Diet, Salt-Free
Hyperkalemia
Mineralocorticoid Effect

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