Reversal of haloperidol-induced extrapyramidal side effects in cebus monkeys by 8-hydroxy-2-(di-n-propylamino)tetralin and its enantiomers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
C L Christoffersen, L T Meltzer

Abstract

(+/-)-8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), (+)-8-OH-DPAT, and (-)-8-OH-DPAT produced dose-related reversals of haloperidol-induced extrapyramidal side effects (EPS) in cebus monkeys, with all compounds producing similar almost complete reversals at 0.1 mg/kg i.m. These compounds were more potent than apomorphine, which reversed haloperidol-induced EPS at 0.3, but not 0.1, mg/kg i.m. The data indicate that the reversal of haloperidol-induced EPS by (+/-)-8-OH-DPAT and its enantiomers is mediated via effects at 5-HT1A receptors, not dopamine D2 receptors. Thus, inclusion of 5-HT1A agonist activity in novel antipsychotics may reduce EPS liability.

Citations

Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Darakhshan Jabeen Haleem, Nadia Hasan Khan
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laurent BardinAdrian Newman-Tancredi
May 21, 2005·Synapse·R Alexander BantickPaul M Grasby
Sep 3, 2005·Synapse·Tiziana AntonelliLuca Ferraro
Mar 30, 2001·Journal of Psychopharmacology·R A BantickP M Grasby
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronan DepoortereBernard Scatton

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