Abstract
(+/-)-8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), (+)-8-OH-DPAT, and (-)-8-OH-DPAT produced dose-related reversals of haloperidol-induced extrapyramidal side effects (EPS) in cebus monkeys, with all compounds producing similar almost complete reversals at 0.1 mg/kg i.m. These compounds were more potent than apomorphine, which reversed haloperidol-induced EPS at 0.3, but not 0.1, mg/kg i.m. The data indicate that the reversal of haloperidol-induced EPS by (+/-)-8-OH-DPAT and its enantiomers is mediated via effects at 5-HT1A receptors, not dopamine D2 receptors. Thus, inclusion of 5-HT1A agonist activity in novel antipsychotics may reduce EPS liability.
Citations
Mar 10, 2000·Brain Research·J Ichikawa, H Y Meltzer
May 5, 2000·European Journal of Pharmacology·E P PrinssenM S Kleven
Nov 15, 2003·Neuropharmacology·E Lorenc-KociS Wolfarth
Apr 13, 2000·Neuropharmacology·A E CorbinT G Heffner
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Darakhshan Jabeen Haleem, Nadia Hasan Khan
Aug 28, 1999·Bioorganic & Medicinal Chemistry·E J HomanC J Grol
Jan 13, 2000·Bioorganic & Medicinal Chemistry·E J HomanC J Grol
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laurent BardinAdrian Newman-Tancredi
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew C McCrearyChris G Kruse
Dec 5, 2000·Behavioural Pharmacology·E P PrinssenM S Kleven
Mar 14, 2007·Behavioural Pharmacology·Laurent BardinRonan Depoortère
May 21, 2005·Synapse·R Alexander BantickPaul M Grasby
Mar 22, 2007·British Journal of Pharmacology·R DepoortèreA Newman-Tancredi
Sep 27, 2006·Synapse·Jeffrey C GlennonAndrew C McCreary
Nov 3, 2004·Life Sciences·Takuro OkaShigetoshi Kuroda
Oct 19, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Helen RosengartenYan Lin
Apr 9, 2001·Brain Research·L S DeshpandeC T Chopde
Aug 5, 2000·Biological Psychiatry·H RollemaS H Zorn
Sep 3, 2005·Synapse·Tiziana AntonelliLuca Ferraro
Mar 30, 2001·Journal of Psychopharmacology·R A BantickP M Grasby
Jan 7, 2017·CNS Spectrums·Yong Kee ChoiFrank I Tarazi
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronan DepoortereBernard Scatton
Dec 17, 2008·Journal of Medicinal Chemistry·Stefania ButiniCaterina Fattorusso