PMID: 2951129Jan 1, 1986

Reversal of insulin resistance in type 1 diabetes following initiation of insulin treatment

Diabetic Medicine : a Journal of the British Diabetic Association
R S GrayB F Clarke

Abstract

The biological action and pharmacokinetics of insulin were assessed in nine type 1 (insulin-dependent) diabetic patients before and after 3 months conventional insulin treatment, and in seven age and weight-matched non-diabetic controls, by means of the euglycaemic insulin clamp technique. The mean (+/- S.E.) metabolic clearance rate of insulin, when infused at 1 mU/kg/min, was similar in untreated and treated diabetic patients and in controls (22.7 +/- 2.0, 19.3 +/- 3.8, and 22.9 +/- 3.3 ml/kg/min) but, when infused at 6 mU/kg/min, was greater (p less than 0.01 and less than 0.01) in untreated patients (18.0 +/- 2.5 ml/kg/min) than in treated patients (11.5 +/- 1.4 ml/kg/min) and controls (12.7 +/- 1.3 ml/kg/min). Insulin-mediated glucose disposal was reduced (p less than 0.01 and less than 0.01) at insulin infusion rates 1 and 6 mU/kg/min in untreated patients (18.5 +/- 1.9 and 33.8 +/- 4.5 mumol/kg/min) when compared with controls (35.8 +/- 3.4 and 62.0 +/- 4.7 mumol/kg/min) and was improved (p less than 0.01 and less than 0.01) following insulin treatment (36.1 +/- 4.6 and 64.8 +/- 4.2 mumol/kg/min). Daily insulin requirement fell by 33% following 3 months insulin treatment with improvement in mean HbA1 from 16.3 +/- 0.7 to...Continue Reading

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Citations

Jul 12, 2002·Diabetes/metabolism Research and Reviews·Carla J Greenbaum
Apr 9, 2011·International Journal of General Medicine·Francisco Arrieta-BlancoAdela Rovira
Jul 1, 1986·The American Journal of the Medical Sciences·M B Davidson
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·N C SchlootT Mandrup-Poulsen
Dec 14, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A KaasHvidoere Study Group on Childhood Diabetes
Sep 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·Y T Kruszynska, P D Home
Jun 29, 2004·Diabetes Care·Etienne LargerBenjamin Rakotoaminina

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