Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine

Biological Psychiatry
V P BakshiM A Geyer

Abstract

Prepulse inhibition (PPI) of startle provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the startle response. PPI deficits observed in schizophrenia patients can be modeled in rats by individual housing from weaning until adulthood. Deficits in PPI produced by isolation rearing can be reversed by antipsychotics. We evaluated the ability of Seroquel and olanzapine to reverse the isolation-induced disruption of PPI. Rats housed for 8 weeks singly or in groups of 3 were tested every 2 weeks after either Seroquel (0, 5.0 mg/kg) or olanzapine (0, 2.5, 5.0 mg/kg). Startle was elicited by 120-dB pulses presented either with or without prepulses (3, 6, or 12 dB above a 65-dB background). Isolation rearing repeatedly disrupted PPI and sometimes increased startle reactivity. Seroquel reversed these deficits without affecting PPI in socially reared controls. Olanzapine (2.5 mg/kg) reversed the isolation rearing-induced PPI deficit and tended to increase basal PPI levels. Both antipsychotics antagonized the isolation rearing-induced increase in startle reactivity. Isolation rearing produces deficits in sensorimotor gating in rats that are reversible by atypical an...Continue Reading

References

Mar 1, 1992·Archives of General Psychiatry·D L BraffM A Geyer
Jan 1, 1991·Psychopharmacology·I K WrightC A Marsden
Feb 1, 1990·Archives of General Psychiatry·D L Braff, M A Geyer
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jan 1, 1993·Psychopharmacology·C F Saller, A I Salama
Feb 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L S WilkinsonT W Robbins
Dec 1, 1993·The American Journal of Psychiatry·K S CadenheadD L Braff
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·N R Swerdlow, M A Geyer
May 1, 1996·The British Journal of Psychiatry. Supplement·S R HirschL A Arvanitis
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C M BeasleyS Hamilton
Jan 1, 1961·The British Journal of Medical Psychology·A MCGHIE, J CHAPMAN

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Citations

Jul 8, 2005·Psychopharmacology·Jackie CiliaDeclan N C Jones
Jan 5, 2011·Psychopharmacology·Katrine FabriciusBjörn Steiniger-Brach
Dec 21, 2000·Current Psychiatry Reports·G A Light, D L Braff
Sep 24, 2013·Neuroscience Letters·Somayeh DashtiAli Shahbazi
Sep 25, 1999·Physiology & Behavior·V P Bakshi, M A Geyer
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·R S MansbachS H Zorn
Aug 27, 1999·Progress in Neurobiology·M Koch
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Femke T A PijlmanJan M van Ree
Jun 14, 2006·Behavioral Neuroscience·Christie BurtonAlison S Fleming
Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Maarten van den Buuse
May 20, 2003·Neurotoxicity Research·Tomás PalomoRichard J. Beninger
May 20, 2003·Neurotoxicity Research·Susan B. Powell, Mark A. Geyer
May 21, 2005·Neuropsychobiology·Maria Luiza Nunes Mamede RosaMarcus Lira Brandão
Aug 15, 2013·Cognitive, Affective & Behavioral Neuroscience·Nurith AmitaiSusan B Powell
Jan 9, 2016·Neuroscience and Biobehavioral Reviews·Rachel Anne Hill
Jun 15, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·V MolinaC Sancho
Jun 7, 2008·Behavioural Brain Research·Jennifer L PerryMichael T Bardo
May 6, 2008·Neuroscience Letters·Federica LocchiRoberto Rimondini
Apr 1, 2011·British Journal of Pharmacology·C A JonesK C F Fone
Jan 22, 2015·Developmental Psychobiology·Lucas CuenyaGiselle Kamenetzky
May 4, 2005·Biological Psychiatry·Yvette M Peters, Patricio O'Donnell
Aug 18, 2004·Biological Psychiatry·Michael K HarteGavin P Reynolds
Sep 7, 2005·Behavioural Brain Research·Daniel Thomas Malone, David Alan Taylor
Jul 30, 2015·Cognitive, Affective & Behavioral Neuroscience·Nurith AmitaiJared W Young

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