Reversal of Long-Term Weight Regain After Roux-en-Y Gastric Bypass Using Liraglutide or Surgical Revision. A Prospective Study.

Obesity Surgery
Fritz F Horber, Rudolf Steffen

Abstract

This study investigates whether pharmacotherapy with liraglutide is similarly effective in reversing weight regain more than 6 years after Roux-en-Y gastric bypass (RYGB) as revisional surgery aimed at restoring restriction. Ninety-five consecutive patients (11 male, 84 female; mean BMI 45 ± 6 kg/m2) undergoing RYGB 9 ± 4 years ago were treated for 24 months as follows: Patients, who gained less than 10% from weight NADIR, served as controls and were provided lifestyle counseling (DC, n = 30). The others were allowed to choose between three different treatment groups: daily s.c. administration of liraglutide (LG, n = 34); endosurgery using Apollo's Overstitch System™ (ES, n = 15), or implantation of a Fobi-ring with pouch resizing (FP, n = 16). Controls kept their weight stable during 24 months of study (- 0.1 ± 1.7 kg/m2). Weight loss was 4.8 ± 2.9 kg/m2 for LG and 5.5 ± 2.9 kg/m2 for FP, both losing more than 85% of regained weight from weight NADIR (p < 0.001). In contrast, weight loss in ES was 1.0 ± 0.9 kg/m2 (i.e., 20% of regained weight). Thirty-seven percent of FP experienced serious complications (p < 0.05) in contrast to the other groups. An improved prevalence of hypertension and dyslipidemia was observed in LG and F...Continue Reading

References

Aug 21, 2007·Surgical Endoscopy·Michael G Sarr
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Dec 11, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Brian A CoakleyRobert W O'Rourke
Aug 17, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A AstrupUNKNOWN NN8022-1807 Investigators
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Ted D AdamsSteven C Hunt
Jul 3, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T A WaddenUNKNOWN NN8022-1923 Investigators
Mar 25, 2015·Obesity Surgery·Stacy A BrethauerUNKNOWN ASMBS Clinical Issues Committee
Jul 3, 2015·The New England Journal of Medicine·Xavier Pi-SunyerUNKNOWN SCALE Obesity and Prediabetes NN8022-1839 Study Group
Dec 18, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Fatima Cody StanfordLouis J Aronne
Sep 21, 2017·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Oct 31, 2017·Obesity Surgery·Vitor Ottoboni BrunaldiEduardo G H de Moura
Feb 8, 2019·Obesity Surgery·Sarfaraz J BaigUNKNOWN Indian Bariatric Surgery Outcome Reporting (IBSOR) Group
May 27, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Katja LinkeRalph Peterli

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass
pharmacotherapy

Software Mentioned

SAS
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Peter N Taylor, Piero Baglioni
The New England Journal of Medicine
David M Gardner, Andrea L Murphy
The New England Journal of Medicine
Elias S Siraj, Kevin Jon Williams
The New England Journal of Medicine
David M Paton
The New England Journal of Medicine
Michael Freemark
© 2021 Meta ULC. All rights reserved